EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR004620 5,10-methylenetetrahydrofolate reductase

Protein matches Help

UniProtKB

Matches:

912 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004620 MTHF_reductase_bac

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00676	fadh2	912
Signatures in BioMart

InterPro Relationships Help

Parent

IPR003171 Methylenetetrahydrofolate reductase

GO Term annotation Help

Process

GO:0009086 methionine biosynthetic process
GO:0055114 oxidation reduction

InterPro annotation

Entry Details in BioMart

Abstract

The enzyme activities methylenetetrahydrofolate reductase (EC:1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC:1.7.99.5) differ in that the former (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while the latter (assigned in many bacteria) is flexible with respect to the acceptor. Both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as one or the other, this family describes the subset of proteins found in bacteria, and currently designated 5,10-methylenetetrahydrofolate reductase. This protein is an FAD-containing flavoprotein.

Structural links Help

PDB - click here

SCOP: c.1.23.1

CATH: 3.20.20.220

Database links Help

Enzyme: EC:1.5.1.20

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004620

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P0AEZ1 5,10-methylenetetrahydrofolate reductase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004620	5,10-methylenetetrahydrofolate reductase
IPR003171	Methylenetetrahydrofolate reductase
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Pejchal R, Sargeant R, Ludwig ML. Structures of NADH and CH3-H4folate complexes of Escherichia coli methylenetetrahydrofolate reductase reveal a spartan strategy for a ping-pong reaction. Biochemistry 44 2005 11447-57 [PubMed: 16114881] http://dx.doi.org/10.1021/bi050533q
	Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat. Struct. Biol. 6 1999 359-65 [PubMed: 10201405] http://dx.doi.org/10.1038/7594
	Pejchal R, Campbell E, Guenther BD, Lennon BW, Matthews RG, Ludwig ML. Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation. Biochemistry 45 2006 4808-18 [PubMed: 16605249] http://dx.doi.org/10.1021/bi052294c

InterPro 23.1