Aspartate--ammonia ligase (asparagine synthetase) EC:6.3.1.1 catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. This family represents one of two non-homologous forms of aspartate--ammonia ligase found in Escherichia coli. This type is also found in Haemophilus influenzae, Treponema pallidum and Lactobacillus delbrueckii, but appears to have a very limited distribution. The fact that the protein from the H. influenzae is more than 70% identical to that from the spirochete T. pallidum, but less than 65% identical to that from the closely related E. coli, strongly suggests lateral transfer.
Nakatsu T, Kato H, Oda J.
Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase.
Nat. Struct. Biol. 5 1998 15-9
[PubMed: 9437423] http://dx.doi.org/10.1038/nsb0198-15
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