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InterPro: IPR004568 Phosphopantethiene-protein transferase

Protein matches Help

UniProtKB

Matches:

1706 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004568 PPantethiene-prot_Trfase

Secondary

IPR002582

Type

Domain

Signatures Help

Database	ID	Name	Proteins
ProDom	PD004282	PPantethiene-prot_Trfase	1540
TIGRFAMs	TIGR00556	pantethn_trn	1658
Signatures in BioMart

InterPro Relationships Help

Parent

IPR008278 4'-phosphopantetheinyl transferase

Children

IPR002582 Holo-[acyl carrier protein] synthase

GO Term annotation Help

Process

GO:0006633 fatty acid biosynthetic process

Function

GO:0000287 magnesium ion binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

This domain is active in transferring the phophopantethiene prosthetic group to its attachment site on enzymes and carrier proteins. Many members of the family containing this domain are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis. Some members are domains of larger proteins involved specialised pathways for the synthesis of unusual molecules including polyketides, atypical fatty acids, and antibiotics.

Structural links Help

PDB - click here

SCOP: d.150.1.1 , d.150.1.2

CATH: 3.90.470.20

Database links Help

Enzyme: EC:2.7.8.7

Blocks: IPB004568

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004568

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O86785 Holo-[acyl-carrier-protein] synthase

P15368 Fatty acid synthase subunit alpha

P19097 Fatty acid synthase subunit alpha

Q55185 Putative 4'-phosphopantetheinyl transferase slr0495

Q6DJH2 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001227	Acyl transferase domain
IPR016039	Thiolase-like
IPR014030	Beta-ketoacyl synthase, N-terminal
IPR016038	Thiolase-like, subgroup
IPR018201	Beta-ketoacyl synthase, active site
IPR008278	4'-phosphopantetheinyl transferase
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR014031	Beta-ketoacyl synthase, C-terminal
IPR004568	Phosphopantethiene-protein transferase
IPR016040	NAD(P)-binding domain
IPR000794	Beta-ketoacyl synthase
IPR002582	Holo-[acyl carrier protein] synthase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL

Publications Help

Additional Reading Open in usermanual
	Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure 8 2000 883-95 [PubMed: 10997907] http://dx.doi.org/10.1016/S0969-2126(00)00178-7
	Reuter K, Mofid MR, Marahiel MA, Ficner R. Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily. EMBO J. 18 1999 6823-31 [PubMed: 10581256] http://dx.doi.org/10.1093/emboj/18.23.6823
	Chirgadze NY, Briggs SL, McAllister KA, Fischl AS, Zhao G. Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis. EMBO J. 19 2000 5281-7 [PubMed: 11032795] http://dx.doi.org/10.1093/emboj/19.20.5281

InterPro 23.1