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InterPro: IPR004472 Dethiobiotin synthase

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UniProtKB

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1257 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR004472 BioD_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_00336	BioD_synth	999
PIRSF	PIRSF006755	DTB_synth	1218
TIGRFAMs	TIGR00347	bioD	1253
Signatures in BioMart

InterPro Relationships Help

Contains

IPR002586 Cobyrinic acid a,c-diamide synthase

GO Term annotation Help

Process

GO:0009102 biotin biosynthetic process

Function

GO:0000287 magnesium ion binding
GO:0004141 dethiobiotin synthase activity
GO:0005524 ATP binding

InterPro annotation

Entry Details in BioMart

Abstract

The enzyme is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP and requires magnesium as a co-factor. The Thr residue at position seven of the seed alignment is necessary for the binding of ATP.

Structural links Help

PDB - click here

SCOP: c.37.1.10

CATH: 3.40.50.300

Database links Help

Enzyme: EC:6.3.3.3

Taxonomic coverage Help

Example proteins Help

A6UQL8 Dethiobiotin synthetase

B0JX07 Dethiobiotin synthetase

O06620 Dethiobiotin synthetase

P53630 Dethiobiotin synthetase

Q55849 Dethiobiotin synthetase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004472	Dethiobiotin synthase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Alexeev D, Baxter RL, Sawyer L. Mechanistic implications and family relationships from the structure of dethiobiotin synthetase. Structure 2 1994 1061-72 [PubMed: 7881906] http://dx.doi.org/10.1016/S0969-2126(94)00109-X
	Kack H, Sandmark J, Gibson KJ, Schneider G, Lindqvist Y. Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis. Protein Sci. 7 1998 2560-6 [PubMed: 9865950] http://www.proteinscience.org/cgi/content/abstract/7/12/2560
	Sandalova T, Schneider G, Kack H, Lindqvist Y. Structure of dethiobiotin synthetase at 0.97 A resolution. Acta Crystallogr. D Biol. Crystallogr. 55 1999 610-24 [PubMed: 10089457] http://dx.doi.org/10.1107/S090744499801381X
	Huang W, Jia J, Gibson KJ, Taylor WS, Rendina AR, Schneider G, Lindqvist Y. Mechanism of an ATP-dependent carboxylase, dethiobiotin synthetase, based on crystallographic studies of complexes with substrates and a reaction intermediate. Biochemistry 34 1995 10985-95 [PubMed: 7669756] http://dx.doi.org/10.1021/bi00035a004
	Kack H, Gibson KJ, Lindqvist Y, Schneider G. Snapshot of a phosphorylated substrate intermediate by kinetic crystallography. Proc. Natl. Acad. Sci. U.S.A. 95 1998 5495-500 [PubMed: 9576910] http://dx.doi.org/10.1073/pnas.95.10.5495

InterPro 23.1