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InterPro: IPR004467 Orotate phosphoribosyl transferase

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UniProtKB

Matches:

1734 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004467 Or_phspho_trans

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00336	pyrE	1734
Signatures in BioMart

InterPro Relationships Help

Parent

IPR000836 Phosphoribosyltransferase

GO Term annotation Help

Process

GO:0006221 pyrimidine nucleotide biosynthetic process

Function

GO:0004588 orotate phosphoribosyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Orotate phosphoribosyl transferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilised to form pyrophosphate and orotidine 5 -monophosphate (OMP) in the presence of divalent cations, preferably Mg2+. In a number of eukaryotes, this protein is fused to a domain that catalyses the reaction (EC:4.1.1.23). The combined activity of EC:2.4.2.10 and EC:4.1.1.23 is termed uridine 5 -monophosphate synthase. The conserved Lys (K) residue at position 101 of the seed alignment has been proposed as the active site for the enzyme.

Structural links Help

PDB - click here

SCOP: c.61.1.1

CATH: 3.40.50.2020

Database links Help

Enzyme: EC:2.4.2.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004467

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P11172 Uridine 5'-monophosphate synthase

P13298 Orotate phosphoribosyltransferase 1

P13439 Uridine 5'-monophosphate synthase

Q01637 Uridine 5'-monophosphate synthase

Q42586 Uridine 5'-monophosphate synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013785	Aldolase-type TIM barrel
IPR001754	Orotidine 5'-phosphate decarboxylase, core
IPR004467	Orotate phosphoribosyl transferase
IPR018089	Orotidine 5'-phosphate decarboxylase, active site
IPR011060	Ribulose-phosphate binding barrel
IPR000836	Phosphoribosyltransferase
IPR014732	Orotidine 5'-phosphate decarboxylase, subfamily 1, core
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Scapin G, Grubmeyer C, Sacchettini JC. Crystal structure of orotate phosphoribosyltransferase. Biochemistry 33 1994 1287-94 [PubMed: 8312245] http://dx.doi.org/10.1021/bi00172a001
	Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry 46 2007 14075-86 [PubMed: 18020427] http://dx.doi.org/10.1021/bi701023z
	Henriksen A, Aghajari N, Jensen KF, Gajhede M. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase. Biochemistry 35 1996 3803-9 [PubMed: 8620002] http://dx.doi.org/10.1021/bi952226y
	Scapin G, Ozturk DH, Grubmeyer C, Sacchettini JC. The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate. Biochemistry 34 1995 10744-54 [PubMed: 7545004] http://dx.doi.org/10.1021/bi00034a006

InterPro 23.1