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InterPro: IPR004456 Cofactor-independent phosphoglycerate mutase, archaeal

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UniProtKB

Matches:

260 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004456 APGAM_arc

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF006392	IPGAM_arch	252
TIGRFAMs	TIGR00306	apgM	237
Signatures in BioMart

InterPro Relationships Help

Children

IPR013371 Homoserine kinase, putative

Contains

IPR017850 Alkaline-phosphatase-like, core domain
IPR019304 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

GO Term annotation Help

Function

GO:0003824 catalytic activity
GO:0046872 metal ion binding

InterPro annotation

Entry Details in BioMart

Abstract

This family represents 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM), it is a metalloenzyme found particularly in archaea and some eubacteria. It is distantly related to the iPGAM (IPR005995) characteristic of plants and many eubacteria. The common active site and metal-binding residues of the phosphatase domain are easily identified, but the putative phosphotransferase domain is highly diverged. These proteins are unrelated to the cofactor-dependent PGAM (PIRSF001490). Activity has been demonstrated for proteins from Methanocaldococcus jannaschii (Methanococcus jannaschii) [1, 2], Pyrococcus furiosus [2], and Sulfolobus solfataricus [3]. These proteins were initially misidentified as phosphonopyruvate decarboxylase.

Database links Help

Enzyme: EC:5.4.2.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004456

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A5ILK6 Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

O57742 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011258	BPG-independent PGAM, N-terminal
IPR004456	Cofactor-independent phosphoglycerate mutase, archaeal
IPR006124	Metalloenzyme
IPR019304	2,3-bisphosphoglycerate-independent phosphoglycerate mutase
IPR017850	Alkaline-phosphatase-like, core domain
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Graham DE, Xu H, White RH. A divergent archaeal member of the alkaline phosphatase binuclear metalloenzyme superfamily has phosphoglycerate mutase activity. FEBS Lett. 517 190-4 2002 [PubMed: 12062435] http://dx.doi.org/10.1016/S0014-5793(02)02619-4
2.	van der Oost J, Huynen MA, Verhees CH. Molecular characterization of phosphoglycerate mutase in archaea. FEMS Microbiol. Lett. 212 111-20 2002 [PubMed: 12076796]
3.	Potters MB, Solow BT, Bischoff KM, Graham DE, Lower BH, Helm R, Kennelly PJ. Phosphoprotein with phosphoglycerate mutase activity from the archaeon Sulfolobus solfataricus. J. Bacteriol. 185 2112-21 2003 [PubMed: 12644480] http://dx.doi.org/10.1128/JB.185.7.2112-2121.2003

InterPro 23.1