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InterPro: IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

Protein matches Help

UniProtKB

Matches:

1523 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004424 IspE

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_00061	IspE	1234
PIRSF	PIRSF010376	IspE	1415
PANTHER	PTHR20861:SF2	IspE	1512
TIGRFAMs	TIGR00154	ispE	1375
Signatures in BioMart

InterPro Relationships Help

Contains

IPR006204 GHMP kinase
IPR013750 GHMP kinase, C-terminal
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
IPR020568 Ribosomal protein S5 domain 2-type fold

GO Term annotation Help

Process

GO:0016114 terpenoid biosynthetic process

Function

GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity

InterPro annotation

Entry Details in BioMart

Abstract

4-diphosphocytidyl-2C-methyl-D-erythritol kinase is a member of the family of GHMP kinases that were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. In Solanum lycopersicum (Tomato) (Lycopersicon esculentum) and Escherichia coli the protein has been indentified as 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis.

Structural links Help

PDB - click here

SCOP: d.14.1.5 , d.58.26.5

CATH: 3.30.230.10

Database links Help

Enzyme: EC:2.7.1.148

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004424

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2BR01 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

O67060 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

O81014 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic

P56848 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic

P72663 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR006204	GHMP kinase
IPR013750	GHMP kinase, C-terminal
IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
IPR004424	4-diphosphocytidyl-2C-methyl-D-erythritol kinase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Wada T, Kuzuyama T, Satoh S, Kuramitsu S, Yokoyama S, Unzai S, Tame JR, Park SY. Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. J. Biol. Chem. 278 2003 30022-7 [PubMed: 12771135] http://dx.doi.org/10.1074/jbc.M304339200
	Miallau L, Alphey MS, Kemp LE, Leonard GA, McSweeney SM, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN. Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase. Proc. Natl. Acad. Sci. U.S.A. 100 2003 9173-8 [PubMed: 12878729] http://dx.doi.org/10.1073/pnas.1533425100
	Luttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proc. Natl. Acad. Sci. U.S.A. 97 2000 1062-7 [PubMed: 10655484] http://dx.doi.org/10.1073/pnas.97.3.1062

InterPro 23.1