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InterPro: IPR004410 Malonyl CoA-acyl carrier protein transacylase

Protein matches Help

UniProtKB

Matches:

1465 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004410 FabD

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00128	fabD	1465
Signatures in BioMart

InterPro Relationships Help

Parent

IPR014043 Acyl transferase

Contains

IPR016036 Malonyl-CoA ACP transacylase, ACP-binding

GO Term annotation Help

Process

GO:0006633 fatty acid biosynthetic process

Function

GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Malonyl CoA-acyl carrier protein transacylase EC:2.3.1.39 is involved in fatty acid biosynthesis and transfers the malonyl moeity from coenzyme A to acyl-carrier protein.

Structural links Help

PDB - click here

SCOP: c.19.1.1 , d.58.23.1

CATH: 3.30.70.250 , 3.40.366.10

Database links Help

Enzyme: EC:2.3.1.39

CluSTr: ALLvsALL:32044:66.3

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004410

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O85140 Malonyl CoA-acyl carrier protein transacylase

P73242 Malonyl CoA-acyl carrier protein transacylase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001227	Acyl transferase domain
IPR004410	Malonyl CoA-acyl carrier protein transacylase
IPR014043	Acyl transferase
IPR016036	Malonyl-CoA ACP transacylase, ACP-binding
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Zhang L, Liu W, Xiao J, Hu T, Chen J, Chen K, Jiang H, Shen X. Malonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein. Protein Sci. 16 2007 1184-92 [PubMed: 17525466] http://dx.doi.org/10.1110/ps.072757307
	Oefner C, Schulz H, D'Arcy A, Dale GE. Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 62 2006 613-8 [PubMed: 16699188] http://dx.doi.org/10.1107/S0907444906009474
	Serre L, Verbree EC, Dauter Z, Stuitje AR, Derewenda ZS. The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component. J. Biol. Chem. 270 1995 12961-4 [PubMed: 7768883] http://dx.doi.org/10.1074/jbc.270.22.12961

InterPro 23.1