EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR004305 TENA/THI-4 protein/Coenzyme PQQ biosynthesis protein C

Protein matches Help

UniProtKB

Matches:

1219 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004305 TENA/THI4/PQQ_synth_PqqC

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03070	TENA_THI-4	1219
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016084 Haem oxygenase-like, multi-helical

Children

IPR011845 Coenzyme PQQ biosynthesis protein C

Found in

IPR017004 Uncharacterised conserved protein UCP032676, PqqC

InterPro annotation

Entry Details in BioMart

Abstract

Proteins containing this domain are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase [1].

The THI-4 protein, which is involved in thiamine biosynthesis, also contains this domain. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4 [2]. The exact molecular function of this domain is uncertain.

Structural links Help

PDB - click here

SCOP: a.132.1.3 , a.132.1.4

CATH: 1.20.910.10

Database links Help

PANDIT: PF03070

Blocks: IPB004305

Pfam Clan: CL0230.4

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004305

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O84616 PqqC-like protein

O94265 Putative phosphomethylpyrimidine kinase 1

P25362 Protein PET18

Q9ASY9 Seed maturation protein PM36 homolog

Q9SWB6 Seed maturation protein PM36

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013749	Phosphomethylpyrimidine kinase type-1
IPR004399	Phosphomethylpyrimidine kinase type-2
IPR004305	TENA/THI-4 protein/Coenzyme PQQ biosynthesis protein C
IPR016084	Haem oxygenase-like, multi-helical
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Pang AS, Nathoo S, Wong SL. Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis. J. Bacteriol. 173 46-54 1991 [PubMed: 1898926] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=1898926&action=stream&blobtype=pdf
2.	Akiyama M, Nakashima H. Molecular cloning of thi-4, a gene necessary for the biosynthesis of thiamine in Neurospora crassa. Curr. Genet. 30 62-7 1996 [PubMed: 8662211] http://dx.doi.org/10.1007/s002940050101

Additional Reading Open in usermanual
	Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr. Ensemble refinement of protein crystal structures: validation and application. Structure 15 2007 1040-52 [PubMed: 17850744] http://dx.doi.org/10.1016/j.str.2007.06.019
	Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF. The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism. Acta Crystallogr. D Biol. Crystallogr. 61 2005 589-98 [PubMed: 15858269] http://dx.doi.org/10.1107/S0907444905005147
	Jenkins AL, Zhang Y, Ealick SE, Begley TP. Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorg. Chem. 36 2008 29-32 [PubMed: 18054064] http://dx.doi.org/10.1016/j.bioorg.2007.10.005
	Magnusson OT, Toyama H, Saeki M, Rojas A, Reed JC, Liddington RC, Klinman JP, Schwarzenbacher R. Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. Proc. Natl. Acad. Sci. U.S.A. 101 2004 7913-8 [PubMed: 15148379] http://dx.doi.org/10.1073/pnas.0402640101
	Toyama H, Fukumoto H, Saeki M, Matsushita K, Adachi O, Lidstrom ME. PqqC/D, which converts a biosynthetic intermediate to pyrroloquinoline quinone. Biochem. Biophys. Res. Commun. 299 2002 268-72 [PubMed: 12437981] http://dx.doi.org/10.1016/S0006-291X(02)02603-7
	Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry 44 2005 2319-29 [PubMed: 15709744] http://dx.doi.org/10.1021/bi0478648

InterPro 23.1