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InterPro: IPR004166 MHCK/EF2 kinase

Protein matches Help

UniProtKB

Matches:

212 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004166 MHCK_EF2_kinase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02816	Alpha_kinase	206
PROSITE profile	PS51158	ALPHA_KINASE	194
SMART	SM00811	Alpha_kinase	149
Signatures in BioMart

InterPro Relationships Help

Parent

IPR011009 Protein kinase-like domain

Found in

IPR017400 Elongation factor 2 kinase

GO Term annotation Help

Process

GO:0006468 protein amino acid phosphorylation

Function

GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

InterPro annotation

Entry Details in BioMart

Abstract

Proteins containing this domain consist of a novel group of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. Proteins include myosin heavy chain kinases [1, 2] and Elongation Factor-2 kinase and a bifunctional ion channel [3].

Structural links Help

PDB - click here

SCOP: d.144.1.5

CATH: 3.30.200.20

Database links Help

Enzyme: EC:2.7.11

PROSITE doc: PDOC51158

PANDIT: PF02816

Blocks: IPB004166

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004166

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O00418 Eukaroytic elongation factor 2 kinase

O01991 Eukaroytic elongation factor 2 kinase

P42527 Myosin heavy chain kinase A

Q923J1 Transient receptor potential cation channel subfamily M member 7

Q925B3 Transient receptor potential cation channel subfamily M member 7

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004166	MHCK/EF2 kinase
IPR011990	Tetratricopeptide-like helical
IPR019775	WD40 repeat, conserved site
IPR006597	Sel1-like
IPR017986	WD40-repeat-containing domain
IPR019782	WD40 repeat 2
IPR005821	Ion transport
IPR019781	WD40 repeat, subgroup
IPR011009	Protein kinase-like domain
IPR011046	WD40 repeat-like-containing domain
IPR001680	WD40 repeat
IPR017400	Elongation factor 2 kinase
IPR020472	G-protein beta WD-40 repeat, region
IPR015943	WD40/YVTN repeat-like-containing domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Futey LM, Medley QG, Cote GP, Egelhoff TT. Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins. J. Biol. Chem. 270 523-9 1995 [PubMed: 7822274] http://dx.doi.org/10.1074/jbc.270.2.523
2.	Cote GP, Luo X, Murphy MB, Egelhoff TT. Mapping of the novel protein kinase catalytic domain of Dictyostelium myosin II heavy chain kinase A. J. Biol. Chem. 272 6846-9 1997 [PubMed: 9054368] http://dx.doi.org/10.1074/jbc.272.11.6846
3.	Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291 1043-7 2001 [PubMed: 11161216] http://dx.doi.org/10.1126/science.1058519

Additional Reading Open in usermanual
	Ryazanov AG, Pavur KS, Dorovkov MV. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr. Biol. 9 1999 R43-5 [PubMed: 10021370] http://dx.doi.org/10.1016/S0960-9822(99)80006-2
	Ryazanov AG, Shestakova EA, Natapov PG. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature 334 1988 170-3 [PubMed: 3386756] http://dx.doi.org/10.1038/334170a0
	Drennan D, Ryazanov AG. Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog. Biophys. Mol. Biol. 85 2004 1-32 [PubMed: 15050379] http://dx.doi.org/10.1016/S0079-6107(03)00060-9
	Yamaguchi H, Matsushita M, Nairn AC, Kuriyan J. Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol. Cell 7 2001 1047-57 [PubMed: 11389851] http://dx.doi.org/10.1016/S1097-2765(01)00256-8

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