EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR004104 Oxidoreductase, C-terminal

Protein matches Help

UniProtKB

Matches:

5260 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004104 OxRdtase_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02894	GFO_IDH_MocA_C	5260
Signatures in BioMart

InterPro Relationships Help

Found in

IPR008354 Glucose-fructose oxidoreductase, bacterial

GO Term annotation Help

Process

GO:0008152 metabolic process
GO:0055114 oxidation reduction

Function

GO:0016491 oxidoreductase activity

InterPro annotation

Entry Details in BioMart

Abstract

Enzymes containing this domain utilise NADP or NAD, and are known as the GFO/IDH/MOCA family in UniProtKB/Swiss-Prot. GFO is a glucose--fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyse the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and galactose metabolic genes; and several hypothetical proteins from yeast, Escherichia coli and Bacillus subtilis.

The oxidoreductase, C-terminal domain is almost always associated with the oxidoreductase, N-terminal domain (see IPR000683).

Structural links Help

PDB - click here

SCOP: d.81.1.5

CATH: 3.30.360.10

Database links Help

Enzyme: EC:1

PANDIT: PF02894

Pfam Clan: CL0218.8

Taxonomic coverage Help

Example proteins Help

P74041 Uncharacterized oxidoreductase sll0816

Q04869 Uncharacterized protein YMR315W

Q3B7J2 Glucose-fructose oxidoreductase domain-containing protein 2

Q3UHD2 Glucose-fructose oxidoreductase domain-containing protein 1

Q9SZ83 Uncharacterized oxidoreductase At4g09670

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000683	Oxidoreductase, N-terminal
IPR016040	NAD(P)-binding domain
IPR004104	Oxidoreductase, C-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Nurizzo D, Halbig D, Sprenger GA, Baker EN. Crystal structures of the precursor form of glucose-fructose oxidoreductase from Zymomonas mobilis and its complexes with bound ligands. Biochemistry 40 2001 13857-67 [PubMed: 11705375] http://dx.doi.org/10.1021/bi011355d
	Kingston RL, Scopes RK, Baker EN. The structure of glucose-fructose oxidoreductase from Zymomonas mobilis: an osmoprotective periplasmic enzyme containing non-dissociable NADP. Structure 4 1996 1413-28 [PubMed: 8994968] http://dx.doi.org/10.1016/S0969-2126(96)00149-9
	Lott JS, Halbig D, Baker HM, Hardman MJ, Sprenger GA, Baker EN. Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation. J. Mol. Biol. 304 2000 575-84 [PubMed: 11099381] http://dx.doi.org/10.1006/jmbi.2000.4245

InterPro 23.1