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InterPro: IPR004013 PHP, C-terminal

Protein matches Help

UniProtKB

Matches:

6227 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004013 PHP_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02811	PHP	6227
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016195 Polymerase/histidinol phosphatase-like

Children

IPR003141 Polymerase/histidinol phosphatase, N-terminal

Found in

IPR005287 Conserved hypothetical protein CHP00375
IPR010140 Histidinol phosphate phosphatase, HisJ
IPR016667 Capsular polysaccharide synthesis, CpsB/CapC

GO Term annotation Help

Function

GO:0003824 catalytic activity

InterPro annotation

Entry Details in BioMart

Abstract

The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain. This family is often associated with an N-terminal region IPR003141.

Structural links Help

PDB - click here

SCOP: c.6.3.1

CATH: 1.20.5.140 , 3.20.20.140 , 3.30.420.10

Database links Help

PANDIT: PF02811

Blocks: IPB004013

Pfam Clan: CL0034.11

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004013

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O14059 Probable histidinol-phosphatase

P10443 DNA polymerase III subunit alpha

P38635 Histidinol-phosphatase

Q57860 Uncharacterized protein MJ0417

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003141	Polymerase/histidinol phosphatase, N-terminal
IPR010140	Histidinol phosphate phosphatase, HisJ
IPR004013	PHP, C-terminal
IPR016195	Polymerase/histidinol phosphatase-like
IPR004365	Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR016027	Nucleic acid-binding, OB-fold-like
IPR011708	Bacterial DNA polymerase III, alpha subunit
IPR004805	DNA polymerase III, alpha subunit
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Teplyakov A, Obmolova G, Khil PP, Howard AJ, Camerini-Otero RD, Gilliland GL. Crystal structure of the Escherichia coli YcdX protein reveals a trinuclear zinc active site. Proteins 51 2003 315-8 [PubMed: 12661000] http://dx.doi.org/10.1002/prot.10352
	Aravind L, Koonin EV. Phosphoesterase domains associated with DNA polymerases of diverse origins. Nucleic Acids Res. 26 1998 3746-52 [PubMed: 9685491] http://dx.doi.org/10.1093/nar/26.16.3746

InterPro 23.1