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InterPro: IPR003892 Ubiquitin system component Cue

Protein matches Help

UniProtKB

Matches:

768 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
Matches in BioMart

Accession

IPR003892 CUE

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02845	CUE	563
PROSITE profile	PS51140	CUE	758
SMART	SM00546	CUE	314
Signatures in BioMart

InterPro Relationships Help

Found in

IPR009060 UBA-like

InterPro annotation

Entry Details in BioMart

Abstract

This domain may be involved in binding ubiquitin-conjugating enzymes (UBCs). CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.

Structural links Help

PDB - click here

SCOP: a.5.2.4

CATH: 1.10.8.10

Database links Help

PROSITE doc: PDOC51140

PANDIT: PF02845

Blocks: IPB003892

Pfam Clan: CL0214.9

Interactions Help

This domain has been experimentally proven to be involved in Protein:Protein interactions.
Representative data is shown with the following example proteins:

Taxonomic coverage Help

Example proteins Help

A1L131 CUE domain-containing protein 2

P34426 Ancient ubiquitous protein 1 homolog

P36075 Ubiquitin-binding protein CUE2

P70295 Ancient ubiquitous protein 1

Q86UW6 NEDD4-binding protein 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002123	Phospholipid/glycerol acyltransferase
IPR003892	Ubiquitin system component Cue
IPR009060	UBA-like
IPR013899	Domain of unknown function DUF1771
IPR002625	Smr protein/MutS2 C-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Zhang PJ, Zhao J, Li HY, Man JH, He K, Zhou T, Pan X, Li AL, Gong WL, Jin BF, Xia Q, Yu M, Shen BF, Zhang XM. CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. EMBO J. 26 2007 1831-42 [PubMed: 17347654] http://dx.doi.org/10.1038/sj.emboj.7601602
	Kang RS, Daniels CM, Francis SA, Shih SC, Salerno WJ, Hicke L, Radhakrishnan I. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell 113 2003 621-30 [PubMed: 12787503] http://dx.doi.org/10.1016/S0092-8674(03)00362-3
	Biederer T, Volkwein C, Sommer T. Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278 1997 1806-9 [PubMed: 9388185] http://dx.doi.org/10.1126/science.278.5344.1806
	Prag G, Misra S, Jones EA, Ghirlando R, Davies BA, Horazdovsky BF, Hurley JH. Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell 113 2003 609-20 [PubMed: 12787502] http://dx.doi.org/10.1016/S0092-8674(03)00364-7
	Donaldson KM, Yin H, Gekakis N, Supek F, Joazeiro CA. Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p. Curr. Biol. 13 2003 258-62 [PubMed: 12573224] http://dx.doi.org/10.1016/S0960-9822(03)00043-5
	Shih SC, Prag G, Francis SA, Sutanto MA, Hurley JH, Hicke L. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 22 2003 1273-81 [PubMed: 12628920] http://dx.doi.org/10.1093/emboj/cdg140
	Ponting CP. Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. Biochem. J. 351 Pt 2 2000 527-35 [PubMed: 11023840] http://dx.doi.org/10.1042/0264-6021:3510527

InterPro 23.1