EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR003859 Metazoa galactosyltransferase

Protein matches Help

UniProtKB

Matches:

288 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003859 Galactosyl_T_2

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02709	Galactosyl_T_2	260
PANTHER	PTHR19300	Galactosyl_T_2	284
Signatures in BioMart

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0016757 transferase activity, transferring glycosyl groups

InterPro annotation

Entry Details in BioMart

Abstract

This is a family of galactosyltransferases from a wide range of metazoa with three related galactosyltransferase activities; all three of which are possessed by one sequence in some cases. The three functions are N-acetyllactosamine synthase (EC:2.4.1.90); beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase (EC:2.4.1.38); and lactose synthase (EC:2.4.1.22). Note that N-acetyllactosamine synthase is a component of lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin N-acetyllactosamine synthase is used.

Structural links Help

PDB - click here

SCOP: c.68.1.2

CATH: 3.90.550.10

Database links Help

Enzyme: EC:2.4.1

PANDIT: PF02709

Blocks: IPB003859

Pfam Clan: CL0110.8

Taxonomic coverage Help

Example proteins Help

A8Y1P7 Beta-1,4-N-acetylgalactosaminyltransferase bre-4

P08037 Beta-1,4-galactosyltransferase 1

P15291 Beta-1,4-galactosyltransferase 1

P15535 Beta-1,4-galactosyltransferase 1

P34548 Probable galactosyltransferase sqv-3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003859	Metazoa galactosyltransferase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Ramasamy V, Ramakrishnan B, Boeggeman E, Qasba PK. The role of tryptophan 314 in the conformational changes of beta1,4-galactosyltransferase-I. J. Mol. Biol. 331 2003 1065-76 [PubMed: 12927542] http://dx.doi.org/10.1016/S0022-2836(03)00790-3
	Ramasamy V, Ramakrishnan B, Boeggeman E, Ratner DM, Seeberger PH, Qasba PK. Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety. J. Mol. Biol. 353 2005 53-67 [PubMed: 16157350] http://dx.doi.org/10.1016/j.jmb.2005.07.050
	Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H. Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J. Biol. Chem. 273 1998 29331-40 [PubMed: 9792633] http://dx.doi.org/10.1074/jbc.273.45.29331
	Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. Proc. Natl. Acad. Sci. U.S.A. 95 1998 472-7 [PubMed: 9435216] http://dx.doi.org/10.1073/pnas.95.2.472
	Ramakrishnan B, Ramasamy V, Qasba PK. Structural snapshots of beta-1,4-galactosyltransferase-I along the kinetic pathway. J. Mol. Biol. 357 2006 1619-33 [PubMed: 16497331] http://dx.doi.org/10.1016/j.jmb.2006.01.088
	Ramakrishnan B, Boeggeman E, Qasba PK. Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine beta-1,4-galactosyltransferase I. Biochemistry 44 2005 3202-10 [PubMed: 15736931] http://dx.doi.org/10.1021/bi0479454
	Ramakrishnan B, Boeggeman E, Qasba PK. Effect of the Met344His mutation on the conformational dynamics of bovine beta-1,4-galactosyltransferase: crystal structure of the Met344His mutant in complex with chitobiose. Biochemistry 43 2004 12513-22 [PubMed: 15449940] http://dx.doi.org/10.1021/bi049007+

InterPro 23.1