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InterPro: IPR003819 Taurine catabolism dioxygenase TauD/TfdA

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Matches:

2445 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003819 Taurine_dOase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02668	TauD	2445
Signatures in BioMart

InterPro Relationships Help

Children

IPR012775 Gamma-butyrobetaine,2-oxoglutarate dioxygenase
IPR012776 Trimethyllysine dioxygenase

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0016491 oxidoreductase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of TauD/TfdA taurine catabolism dioxygenases. The Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulphonic acid) as a sulphur source and is expressed only under conditions of sulphate starvation. TauD is an alpha-ketoglutarate-dependent dioxygenase catalyzing the oxygenolytic release of sulphite from taurine [1]. The 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. (strain RASC) also belongs to this family [2]. TfdA from Ralstonia eutropha (Alcaligenes eutrophus) is a 2,4-D monooxygenase [3].

Structural links Help

PDB - click here

SCOP: b.82.2.2 , b.82.2.5 , b.82.2.8

CATH: 3.60.130.10

Database links Help

Enzyme: EC:1

PANDIT: PF02668

Blocks: IPB003819

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003819

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O75936 Gamma-butyrobetaine dioxygenase

P23180 Uncharacterized oxidoreductase YHL021C

Q19000 Probable gamma-butyrobetaine dioxygenase

Q91ZE0 Trimethyllysine dioxygenase, mitochondrial

Q9LIG0 Clavaminate synthase-like protein At3g21360

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012776	Trimethyllysine dioxygenase
IPR003819	Taurine catabolism dioxygenase TauD/TfdA
IPR012775	Gamma-butyrobetaine,2-oxoglutarate dioxygenase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Eichhorn E, van der Ploeg JR, Kertesz MA, Leisinger T. Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli. J. Biol. Chem. 272 23031-6 1997 [PubMed: 9287300] http://dx.doi.org/10.1074/jbc.272.37.23031
2.	Suwa Y, Wright AD, Fukimori F, Nummy KA, Hausinger RP, Holben WE, Forney LJ. Characterization of a chromosomally encoded 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. strain RASC. Appl. Environ. Microbiol. 62 2464-9 1996 [PubMed: 8779585] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8779585
3.	Streber WR, Timmis KN, Zenk MH. Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134. J. Bacteriol. 169 2950-5 1987 [PubMed: 3036764] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=3036764

Additional Reading Open in usermanual
	Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr. Ensemble refinement of protein crystal structures: validation and application. Structure 15 2007 1040-52 [PubMed: 17850744] http://dx.doi.org/10.1016/j.str.2007.06.019
	Bitto E, Bingman CA, Allard ST, Wesenberg GE, Aceti DJ, Wrobel RL, Frederick RO, Sreenath H, Vojtik FC, Jeon WB, Newman CS, Primm J, Sussman MR, Fox BG, Markley JL, Phillips GN Jr. The structure at 2.4 A resolution of the protein from gene locus At3g21360, a putative Fe(II)/2-oxoglutarate-dependent enzyme from Arabidopsis thaliana. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 2005 469-72 [PubMed: 16511070] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=16511070
	Clifton IJ, Doan LX, Sleeman MC, Topf M, Suzuki H, Wilmouth RC, Schofield CJ. Crystal structure of carbapenem synthase (CarC). J. Biol. Chem. 278 2003 20843-50 [PubMed: 12611886] http://dx.doi.org/10.1074/jbc.M213054200
	Muller I, Stuckl C, Wakeley J, Kertesz M, Uson I. Succinate complex crystal structures of the alpha-ketoglutarate-dependent dioxygenase AtsK: steric aspects of enzyme self-hydroxylation. J. Biol. Chem. 280 2005 5716-23 [PubMed: 15542595] http://dx.doi.org/10.1074/jbc.M410840200
	Muller I, Kahnert A, Pape T, Sheldrick GM, Meyer-Klaucke W, Dierks T, Kertesz M, Uson I. Crystal structure of the alkylsulfatase AtsK: insights into the catalytic mechanism of the Fe(II) alpha-ketoglutarate-dependent dioxygenase superfamily. Biochemistry 43 2004 3075-88 [PubMed: 15023059] http://dx.doi.org/10.1021/bi035752v
	Ruetschi U, Nordin I, Odelhog B, Jornvall H, Lindstedt S. gamma-Butyrobetaine hydroxylase. Structural characterization of the Pseudomonas enzyme. Eur. J. Biochem. 213 1993 1075-80 [PubMed: 8504802] http://dx.doi.org/10.1111/j.1432-1033.1993.tb17855.x

InterPro 23.1