EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR003817 Phosphatidylserine decarboxylase-related

Protein matches Help

UniProtKB

Matches:

1639 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003817 PS_Dcarbxylase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02666	PS_Dcarbxylase	1639
Signatures in BioMart

InterPro Relationships Help

Children

IPR004428 Phosphatidylserine decarboxylase-related protein
IPR005221 Phosphatidylserine decarboxylase

GO Term annotation Help

Process

GO:0008654 phospholipid biosynthetic process

Function

GO:0004609 phosphatidylserine decarboxylase activity

InterPro annotation

Entry Details in BioMart

Abstract

Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [1]. Phosphatidylserine decarboxylases EC:4.1.1.65 is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids [2].

Database links Help

Enzyme: EC:4.1.1.65

PANDIT: PF02666

Blocks: IPB003817

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003817

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0K936 Phosphatidylserine decarboxylase proenzyme

P39006 Phosphatidylserine decarboxylase proenzyme 1, mitochondrial

Q10949 Phosphatidylserine decarboxylase proenzyme

Q8BSF4 Phosphatidylserine decarboxylase proenzyme

Q9UG56 Phosphatidylserine decarboxylase proenzyme

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004428	Phosphatidylserine decarboxylase-related protein
IPR005221	Phosphatidylserine decarboxylase
IPR003817	Phosphatidylserine decarboxylase-related

Publications Open in usermanual
1.	Trotter PJ, Pedretti J, Voelker DR. Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. J. Biol. Chem. 268 21416-24 1993 [PubMed: 8407984] http://intl.jbc.org/cgi/reprint/268/28/21416.pdf
2.	Trotter PJ, Pedretti J, Yates R, Voelker DR. Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. J. Biol. Chem. 270 6071-80 1995 [PubMed: 7890740] http://dx.doi.org/10.1074/jbc.270.11.6071

Additional Reading Open in usermanual
	Matsumoto K, Okada M, Horikoshi Y, Matsuzaki H, Kishi T, Itaya M, Shibuya I. Cloning, sequencing, and disruption of the Bacillus subtilis psd gene coding for phosphatidylserine decarboxylase. J. Bacteriol. 180 1998 100-6 [PubMed: 9422599] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=9422599

InterPro 23.1