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InterPro: IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase

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1755 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR003737 GlcNAc_PIno_de-acetylase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02585	PIG-L	1747
PANTHER	PTHR12993	PIGL/MshB	1428
Signatures in BioMart

InterPro Relationships Help

Children

IPR017810 Mycothiol biosynthesis protein, MshB
IPR017811 Mycothiol conjugate amidase, Mca

InterPro annotation

Entry Details in BioMart

Abstract

A number of the members of this family have been characterised as a probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, (EC:3.5.1.89) that catalyses the second step in glycosylphosphatidylinositol (GPI) biosynthesis [1, 2].

Structural links Help

PDB - click here

SCOP: c.134.1.1

CATH: 3.40.50.10320

Database links Help

Enzyme: EC:3

PANDIT: PF02585

Blocks: IPB003737

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003737

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O31857 Uncharacterized deacetylase yojG

P23797 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Q5SX19 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Q5UQW3 Uncharacterized protein L374

Q9Y2B2 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003737	N-acetylglucosaminyl phosphatidylinositol deacetylase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Watanabe R, Ohishi K, Maeda Y, Nakamura N, Kinoshita T. Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis. Biochem. J. 339 ( Pt 1) 185-92 1999 [PubMed: 10085243] http://dx.doi.org/10.1042/0264-6021:3390185
2.	Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J. Biol. Chem. 278 47166-70 2003 [PubMed: 12958317] http://dx.doi.org/10.1074/jbc.M308914200

Additional Reading Open in usermanual
	Fadouloglou VE, Kotsifaki D, Gazi AD, Fellas G, Meramveliotaki C, Deli A, Psylinakis E, Bouriotis V, Kokkinidis M. Purification, crystallization and preliminary characterization of a putative LmbE-like deacetylase from Bacillus cereus. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 2006 261-4 [PubMed: 16511317]
	Fadouloglou VE, Deli A, Glykos NM, Psylinakis E, Bouriotis V, Kokkinidis M. Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus. FEBS J. 274 2007 3044-54 [PubMed: 17501983] http://dx.doi.org/10.1111/j.1742-4658.2007.05834.x
	Aggarwal VK, Grainger RS, Newton GK, Spargo PL, Hobson AD, Adams H. Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton. Org. Biomol. Chem. 1 2003 1884-93 [PubMed: 12945769] http://dx.doi.org/10.1039/b302834h
	Handa N, Terada T, Kamewari Y, Hamana H, Tame JR, Park SY, Kinoshita K, Ota M, Nakamura H, Kuramitsu S, Shirouzu M, Yokoyama S. Crystal structure of the conserved protein TT1542 from Thermus thermophilus HB8. Protein Sci. 12 2003 1621-32 [PubMed: 12876312] http://dx.doi.org/10.1110/ps.g03104003
	McCarthy AA, Peterson NA, Knijff R, Baker EN. Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J. Mol. Biol. 335 2004 1131-41 [PubMed: 14698305] http://dx.doi.org/10.1016/j.jmb.2003.11.034

InterPro 23.1