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InterPro: IPR003674 Oligosaccharyl transferase, STT3 subunit

Protein matches Help

UniProtKB

Matches:

447 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003674 Oligo_trans_STT3

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02516	STT3	447
Signatures in BioMart

GO Term annotation Help

Process

GO:0006486 protein amino acid glycosylation

Function

GO:0004576 oligosaccharyl transferase activity

Component

GO:0016020 membrane

InterPro annotation

Entry Details in BioMart

Abstract

N-linked glycosylation is a ubiquitous protein modification, and is essential for viability in eukaryotic cells. A lipid-linked core-oligosaccharide is assembled at the membrane of the endoplasmic reticulum and transferred to selected asparagine residues of nascent polypeptide chains by the oligosaccharyl transferase (OTase) complex [1].

This family consists of the oligsacharyl transferase STT3 subunit and related proteins. The STT3 subunit is part of the oligosccharyl transferase (OTase) complex of proteins and is required for its activity [1].

Database links Help

Enzyme: EC:2.4.1.119

PANDIT: PF02516

Blocks: IPB003674

Pfam Clan: CL0111.7

Taxonomic coverage Help

Example proteins Help

P39007 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

P46975 Oligosaccharyl transferase subunit STT3 homolog

P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

P46978 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Q2KJI2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003674	Oligosaccharyl transferase, STT3 subunit
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Zufferey R, Knauer R, Burda P, Stagljar I, te Heesen S, Lehle L, Aebi M. STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo. EMBO J. 14 4949-60 1995 [PubMed: 7588624] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=7588624

Additional Reading Open in usermanual
	Hong G, Deleersnijder W, Kozak CA, Van Marck E, Tylzanowski P, Merregaert J. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. Genomics 31 1996 295-300 [PubMed: 8838310] http://dx.doi.org/10.1006/geno.1996.0051

InterPro 23.1