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InterPro: IPR003644 Na-Ca exchanger/integrin-beta4

Protein matches Help

UniProtKB

Matches:

993 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003644 Calx_beta

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03160	Calx-beta	993
SMART	SM00237	Calx_beta	637
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004836 Sodium/calcium exchanger protein
IPR012013 Integrin beta-4 subunit

GO Term annotation Help

Process

GO:0007154 cell communication

Component

GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

The calx-beta motif is present as a tandem repeat in the cytoplasmic domains of Calx Na-Ca exchangers, which are used to expel calcium from cells. This motif overlaps domains used for calcium binding and regulation. The calx-beta motif is also present in the cytoplasmic tail of mammalian integrin-beta4, which mediates the bi-directional transfer of signals across the plasma membrane, as well as in some cyanobacterial proteins. This motif contains a series of beta-strands and turns that form a self-contained beta-sheet [1, 2].

Structural links Help

PDB - click here

SCOP: b.1.27.1

Database links Help

PANDIT: PF03160

Blocks: IPB003644

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003644

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2A863 Integrin beta-4

P16144 Integrin beta-4

P23685 Sodium/calcium exchanger 1

Q9GV77 Extracellular matrix protein 3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012896	Integrin beta subunit, tail
IPR002369	Integrin beta subunit, N-terminal
IPR001169	Integrin beta subunit, C-terminal
IPR012013	Integrin beta-4 subunit
IPR008957	Fibronectin, type III-like fold
IPR002126	Cadherin
IPR004836	Sodium/calcium exchanger protein
IPR001623	Heat shock protein DnaJ, N-terminal
IPR004837	Sodium/calcium exchanger membrane region
IPR002987	Sodium/calcium exchanger, isoform 1
IPR003659	Plexin/semaphorin/integrin
IPR015812	Integrin beta subunit
IPR013032	EGF-like region, conserved site
IPR003644	Na-Ca exchanger/integrin-beta4
IPR003961	Fibronectin, type III
IPR003962	Fibronectin, type III subdomain
IPR002035	von Willebrand factor, type A
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Schwarz EM, Benzer S. Calx, a Na-Ca exchanger gene of Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 94 10249-54 1997 [PubMed: 9294196] http://dx.doi.org/10.1073/pnas.94.19.10249
2.	Schwarz E, Benzer S. The recently reported NIbeta domain is already known as the Calx-beta motif. Trends Biochem. Sci. 24 260 1999 [PubMed: 10390612] http://dx.doi.org/10.1016/S0968-0004(99)01422-X

Additional Reading Open in usermanual
	Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J. The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. J. Biol. Chem. 281 2006 21577-81 [PubMed: 16774926] http://dx.doi.org/10.1074/jbc.C600117200
	Hilge M, Aelen J, Vuister GW. Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors. Mol. Cell 22 2006 15-25 [PubMed: 16600866] http://dx.doi.org/10.1016/j.molcel.2006.03.008

InterPro 24.0