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InterPro: IPR003615 HNH nuclease

Protein matches Help

UniProtKB

Matches:

5675 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003615 HNH_nuc

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00507	HNHc	5675
Signatures in BioMart

InterPro Relationships Help

Children

IPR002711 HNH endonuclease

Found in

IPR007979 ICEA
IPR010145 CRISPR-associated protein, SAG0894
IPR010373 Protein of unknown function DUF968
IPR011396 Uncharacterised conserved protein UCP030850
IPR013467 Conserved hypothetical protein CHP02646
IPR013492 CRISPR-associated large protein

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in HNH family of nucleases that includes yeast intron 1 protein, MutS, and bacterial colicins and pyocins. They are found in bacteria, viruses and eukaryotes.

Structural links Help

PDB - click here

SCOP: d.4.1.1 , d.4.1.3

CATH: 3.90.540.10

Database links Help

Blocks: IPB003615

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003615

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P03875 Putative COX1/OXI3 intron 1 protein

P04419 Colicin-E2

P34081 DNA endonuclease I-HmuI

Q5FWF4 Zinc finger Ran-binding domain-containing protein 3

Q6NZP1 Zinc finger Ran-binding domain-containing protein 3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003647	Intron encoded nuclease
IPR000442	Intron maturase, type II
IPR016128	Pyosin/cloacin, translocation
IPR003615	HNH nuclease
IPR003058	Cloacin
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR000477	RNA-directed DNA polymerase (reverse transcriptase)
IPR001650	DNA/RNA helicase, C-terminal
IPR002711	HNH endonuclease
IPR001876	Zinc finger, RanBP2-type
IPR000883	Cytochrome c oxidase, subunit I
IPR014001	DEAD-like helicase, N-terminal
IPR010902	NUMOD4
IPR000330	SNF2-related
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Wang YT, Yang WJ, Li CL, Doudeva LG, Yuan HS. Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases. Nucleic Acids Res. 35 2007 584-94 [PubMed: 17175542] http://dx.doi.org/10.1093/nar/gkl621
	Huang H, Yuan HS. The conserved asparagine in the HNH motif serves an important structural role in metal finger endonucleases. J. Mol. Biol. 368 2007 812-21 [PubMed: 17368670] http://dx.doi.org/10.1016/j.jmb.2007.02.044
	Doudeva LG, Huang H, Hsia KC, Shi Z, Li CL, Shen Y, Cheng YS, Yuan HS. Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+. Protein Sci. 15 2006 269-80 [PubMed: 16434744] http://dx.doi.org/10.1110/ps.051903406
	Joachimiak LA, Kortemme T, Stoddard BL, Baker D. Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface. J. Mol. Biol. 361 2006 195-208 [PubMed: 16831445] http://dx.doi.org/10.1016/j.jmb.2006.05.022
	Hsia KC, Chak KF, Liang PH, Cheng YS, Ku WY, Yuan HS. DNA binding and degradation by the HNH protein ColE7. Structure 12 2004 205-14 [PubMed: 14962381] http://dx.doi.org/10.1016/S0969-2126(04)00006-1

InterPro 24.0