EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR003603 U2A'/phosphoprotein 32 family A, C-terminal

Protein matches Help

UniProtKB

Matches:

600 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003603 U2A'_phosphoprotein32A_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00446	LRRcap	600
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This motif occurs C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins. Examples from the metazoa are described as either "Acidic leucine-rich nuclear phosphoprotein 32 family member A" or have been characterised as U2A', the protein that interacts with U2B'' facilitating the interaction with U2 snRNA. U2A' is required for the spliceosome assembly and the efficient addition of U2 snRNP onto the pre-mRNA [1]. The crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA has been described [2].

Structural links Help

PDB - click here

SCOP: c.10.2.3 , c.10.2.4 , c.10.3.1 , d.58.7.2

CATH: 3.80.10.10

Database links Help

Blocks: IPB003603

Taxonomic coverage Help

Example proteins Help

O01615 Acidic leucine-rich nuclear phosphoprotein 32-related protein 2

O35381 Acidic leucine-rich nuclear phosphoprotein 32 family member A

P09661 U2 small nuclear ribonucleoprotein A'

Q08963 U2 small nuclear ribonucleoprotein A'

Q9V4Q8 Probable U2 small nuclear ribonucleoprotein A'

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR001611	Leucine-rich repeat
IPR003603	U2A'/phosphoprotein 32 family A, C-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Caspary F, Seraphin B. The yeast U2A'/U2B complex is required for pre-spliceosome formation. EMBO J. 17 6348-58 1998 [PubMed: 9799242] http://dx.doi.org/10.1093/emboj/17.21.6348
2.	Price SR, Evans PR, Nagai K. Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA. Nature 394 645-50 1998 [PubMed: 9716128] http://dx.doi.org/10.1038/29234

Additional Reading Open in usermanual
	Wu H, Maciejewski MW, Marintchev A, Benashski SE, Mullen GP, King SM. Solution structure of a dynein motor domain associated light chain. Nat. Struct. Biol. 7 2000 575-9 [PubMed: 10876244] http://dx.doi.org/10.1038/76804
	Liker E, Fernandez E, Izaurralde E, Conti E. The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. EMBO J. 19 2000 5587-98 [PubMed: 11060011] http://dx.doi.org/10.1093/emboj/19.21.5587
	Ho DN, Coburn GA, Kang Y, Cullen BR, Georgiadis MM. The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proc. Natl. Acad. Sci. U.S.A. 99 2002 1888-93 [PubMed: 11854490] http://dx.doi.org/10.1073/pnas.042698599
	Wu H, Blackledge M, Maciejewski MW, Mullen GP, King SM. Relaxation-based structure refinement and backbone molecular dynamics of the dynein motor domain-associated light chain. Biochemistry 42 2003 57-71 [PubMed: 12515539] http://dx.doi.org/10.1021/bi026762j

InterPro 24.0