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InterPro: IPR003594 ATPase-like, ATP-binding domain
Protein matches
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UniProtKB Matches: 70830 proteins |
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Accession
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IPR003594 ATPase-like_ATP-bd |
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Type
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Domain |
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Signatures
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InterPro Relationships
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Children
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IPR004358 Signal transduction histidine kinase-related protein, C-terminal
IPR020575 Heat shock protein Hsp90, N-terminal
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Found in
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IPR001241 DNA topoisomerase, type IIA, subunit B or N-terminal
IPR001404 Chaperone protein htpG
IPR002099 DNA mismatch repair protein
IPR005467 Signal transduction histidine kinase, core
IPR005734 DNA topoisomerase VI, subunit B
IPR005737 DNA topoisomerase IV, subunit B, Gram-negative
IPR005740 DNA topoisomerase IV, subunit B, Gram-positive
IPR006290 Signal transduction histidine kinase, heavy metal sensor
IPR008358 Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB
IPR010193 Anti-sigma B factor
IPR010194 Anti-sigma F factor
IPR011186 DNA mismatch repair protein Mlh1
IPR011557 DNA gyrase, subunit B
IPR012129 Phytochrome A/B/C/D/E
IPR014285 Nitrogen fixation negative regulator NifL
IPR014525 Signal transduction histidine kinase, hybrid-type, ethylene sensor
IPR014763 DNA mismatch repair protein, N-terminal
IPR015434 Post Meiotic Segregation 2
IPR015566 Molecular chaperone, heat shock protein, endoplasmin
IPR016380 Signal transduction histidine kinase, nitrate/nitrite-sensing
IPR016381 Signal transduction histidine kinase, DegS
IPR016781 Anti-sigma regulatory factor, PmgA, predicted
IPR017171 Signal transduction histidine kinase, MctS
IPR017202 Signal transduction histidine kinase, LiaS
IPR017204 Signal transduction histidine kinase, STH3221, predicted
IPR017205 Signal transduction histidine kinase, ChrS
IPR017206 Signal transduction histidine kinase, hybrid-type, BC3207, predicted
IPR020667 DNA mismatch repair protein, MutL
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Contains
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IPR014762 DNA mismatch repair, conserved site
IPR019805 Heat shock protein Hsp90, conserved site
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GO Term annotation
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Function
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GO:0005524 ATP binding
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InterPro annotation
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 Entry Details in BioMart
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Abstract
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This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [1], heat shock protein HSP90 [2, 3, 4], phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, alpha/beta, which contains an 8-stranded mixed beta-sheet.
More information about this protein can be found at Protein of the Month: DNA Topoisomerase [5].
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Structural links
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Database links
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Interactions
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This domain has been experimentally proven to be involved in Protein:Protein interactions. Representative
data is shown with the following
example proteins:
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Example proteins
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O55028 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
P02828 Heat shock protein 83
P02829 ATP-dependent molecular chaperone HSP82
P07900 Heat shock protein HSP 90-alpha
P34534 Putative DNA topoisomerase 2, mitochondrial
More proteins
Example Proteins Key
| InterPro entry accession number/name and structure databases |
Colour code |
| IPR001154 |
DNA topoisomerase II, eukaryotic-type |
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| IPR001241 |
DNA topoisomerase, type IIA, subunit B or N-terminal |
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| IPR020568 |
Ribosomal protein S5 domain 2-type fold |
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| IPR013506 |
DNA topoisomerase, type IIA, subunit B, region 2 |
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| IPR019805 |
Heat shock protein Hsp90, conserved site |
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| IPR005467 |
Signal transduction histidine kinase, core |
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| IPR003594 |
ATPase-like, ATP-binding domain |
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| IPR020575 |
Heat shock protein Hsp90, N-terminal |
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| IPR020576 |
Heat shock protein Hsp90, C-terminal |
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| IPR013760 |
DNA topoisomerase, type IIA, central |
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| IPR018522 |
DNA topoisomerase, type IIA, conserved site |
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| IPR013757 |
DNA topoisomerase, type IIA, subunit A, alpha-helical |
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| IPR018955 |
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, mitochondrial |
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| IPR013759 |
DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta |
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| IPR002205 |
DNA topoisomerase, type IIA, subunit A or C-terminal |
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| IPR014721 |
Ribosomal protein S5 domain 2-type fold, subgroup |
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| IPR001404 |
Chaperone protein htpG |
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| IPR004358 |
Signal transduction histidine kinase-related protein, C-terminal |
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PDB Chain |
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ModBase |
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CATH Domain |
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SWISS-MODEL |
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SCOP Domain |
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Publications
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1.
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Bellon S, Parsons JD, Wei Y, Hayakawa K, Swenson LL, Charifson PS, Lippke JA, Aldape R, Gross CH.
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob. Agents Chemother. 48 1856-64 2004
[PubMed: 15105144]
http://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004
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2.
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Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT.
Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone.
J. Biol. Chem. 279 46162-71 2004
[PubMed: 15292259]
http://dx.doi.org/10.1074/jbc.M405253200
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3.
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Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH.
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).
Cell 116 87-98 2004
[PubMed: 14718169]
http://dx.doi.org/10.1016/S0092-8674(03)01027-4
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4.
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Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE.
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Chem. Biol. 11 775-85 2004
[PubMed: 15217611]
http://dx.doi.org/10.1016/j.chembiol.2004.03.033
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5.
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McDowall J.
Protein of the Month: DNA Topoisomerase.
2006
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Additional Reading
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Brough PA, Aherne W, Barril X, Borgognoni J, Boxall K, Cansfield JE, Cheung KM, Collins I, Davies NG, Drysdale MJ, Dymock B, Eccles SA, Finch H, Fink A, Hayes A, Howes R, Hubbard RE, James K, Jordan AM, Lockie A, Martins V, Massey A, Matthews TP, McDonald E, Northfield CJ, Pearl LH, Prodromou C, Ray S, Raynaud FI, Roughley SD, Sharp SY, Surgenor A, Walmsley DL, Webb P, Wood M, Workman P, Wright L.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem. 51 2008 196-218
[PubMed: 18020435]
http://dx.doi.org/10.1021/jm701018h
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Zhao X, Copeland DM, Soares AS, West AH.
Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog.
J. Mol. Biol. 375 2008 1141-51
[PubMed: 18076904]
http://dx.doi.org/10.1016/j.jmb.2007.11.045
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Congreve M, Chessari G, Tisi D, Woodhead AJ.
Recent developments in fragment-based drug discovery.
J. Med. Chem. 51 2008 3661-80
[PubMed: 18457385]
http://dx.doi.org/10.1021/jm8000373
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Lin Z, Ho CW, Grierson D.
AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis.
J. Exp. Bot. 60 2009 3697-714
[PubMed: 19567478]
http://dx.doi.org/10.1093/jxb/erp209
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Green T, Grigorian A, Klyuyeva A, Tuganova A, Luo M, Popov KM.
Structural and functional insights into the molecular mechanisms responsible for the regulation of pyruvate dehydrogenase kinase 2.
J. Biol. Chem. 283 2008 15789-98
[PubMed: 18387944]
http://dx.doi.org/10.1074/jbc.M800311200
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Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.
Molecular characterization of macbecin as an Hsp90 inhibitor.
J. Med. Chem. 51 2008 2853-7
[PubMed: 18357975]
http://dx.doi.org/10.1021/jm701558c
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