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InterPro: IPR003586 Hedgehog/intein hint domain, C-terminal

Protein matches Help

UniProtKB

Matches:

477 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003586 Hedgehog_hint_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SMART	SM00305	HintC	477
Signatures in BioMart

InterPro Relationships Help

Found in

IPR001657 Peptidase C46, hedgehog protein
IPR001767 Peptidase C46, hedgehog protein, hint region

InterPro annotation

Entry Details in BioMart

Abstract

Hedgehog proteins are involved in intracellular signalling required for a variety of patterning events during development. The hint domain is found in these proteins, as well as several proteins which contain inteins and undergo protein splicing. These include the V-type ATP synthase alpha chain from Pyrococcus and the Guillardia replicative DNA helicase DNAB. The Hedgehog/Intein domain has been split to accommodate large insertions of endonucleases. This entry is the C-terminal region.

Structural links Help

PDB - click here

SCOP: b.86.1.1 , b.86.1.2 , c.37.1.11 , c.37.1.20 , d.261.1.1 , e.8.1.1

CATH: 2.170.16.10 , 3.40.50.300

Database links Help

Blocks: IPB003586

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003586

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O43323 Desert hedgehog protein

P17255 V-type proton ATPase catalytic subunit A

P91573 Warthog protein 6

Q02936 Protein hedgehog

Q62226 Sonic hedgehog protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004042	Intein DOD homing endonuclease
IPR003586	Hedgehog/intein hint domain, C-terminal
IPR020003	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain, active site
IPR007869	Homing endonuclease
IPR003587	Hedgehog/intein hint, N-terminal
IPR007868	Hom-end-associated Hint
IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal
IPR001657	Peptidase C46, hedgehog protein
IPR006142	Intein
IPR001767	Peptidase C46, hedgehog protein, hint region
IPR006141	Intein splicing site
IPR000320	Hedgehog, N-terminal signaling domain
IPR000793	ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
IPR009045	Hedgehog/DD-peptidase, zinc-binding motif
IPR018118	ATPase, F1/A1 complex, alpha/beta subunit, N-terminal
IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Mizutani R, Anraku Y, Satow Y. Protein splicing of yeast VMA1-derived endonuclease via thiazolidine intermediates. 11 2004 109-12 [PubMed: 14646148]
	Moure CM, Gimble FS, Quiocho FA. Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence. Nat. Struct. Biol. 9 2002 764-70 [PubMed: 12219083] http://dx.doi.org/10.1038/nsb840
	Okada C, Maegawa Y, Yao M, Tanaka I. Crystal structure of an RtcB homolog protein (PH1602-extein protein) from Pyrococcus horikoshii reveals a novel fold. Proteins 63 2006 1119-22 [PubMed: 16485279] http://dx.doi.org/10.1002/prot.20912
	Ding Y, Xu MQ, Ghosh I, Chen X, Ferrandon S, Lesage G, Rao Z. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J. Biol. Chem. 278 2003 39133-42 [PubMed: 12878593] http://dx.doi.org/10.1074/jbc.M306197200
	Datta S, Ganesh N, Chandra NR, Muniyappa K, Vijayan M. Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition. Proteins 50 2003 474-85 [PubMed: 12557189] http://dx.doi.org/10.1002/prot.10315

InterPro 23.1