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InterPro: IPR003501 Phosphotransferase system, lactose/cellobiose-specific IIB subunit

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UniProtKB

Matches:

3575 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR003501 PTS_IIB_lac

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02302	PTS_IIB	3575
Signatures in BioMart

InterPro Relationships Help

Children

IPR013012 Phosphotransferase system, EIIB component, type 3

Found in

IPR017180 Phosphotransferase system component IIBC, sugar-specific, predicted

Contains

IPR013011 Phosphotransferase system, EIIB component, type 2

GO Term annotation Help

Process

GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system

Function

GO:0005351 sugar:hydrogen symporter activity

InterPro annotation

Entry Details in BioMart

Abstract

The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases. This signature is often found downstream of IPR003352.

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PDB - click here

SCOP: c.44.2.1

CATH: 3.40.50.10370 , 3.40.50.270

Database links Help

Enzyme: EC:2.7.1.69

PANDIT: PF02302

Blocks: IPB003501

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003501

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00550 PTS system mannitol-specific EIICBA component

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003501	Phosphotransferase system, lactose/cellobiose-specific IIB subunit
IPR003352	Phosphotransferase system, EIIC
IPR002178	Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
IPR004718	Phosphotransferase system, mannitol-specific enzyme IIC
IPR016152	Phosphotransferase/anion transporter
IPR013014	Phosphotransferase system, EIIC component, type 2
IPR013011	Phosphotransferase system, EIIB component, type 2
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Legler PM, Cai M, Peterkofsky A, Clore GM. Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IImannitol of the Escherichia coli phosphotransferase system. J. Biol. Chem. 279 2004 39115-21 [PubMed: 15258141] http://dx.doi.org/10.1074/jbc.M406764200
	Ab E, Schuurman-Wolters GK, Nijlant D, Dijkstra K, Saier MH, Robillard GT, Scheek RM. NMR structure of cysteinyl-phosphorylated enzyme IIB of the N,N'-diacetylchitobiose-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. J. Mol. Biol. 308 2001 993-1009 [PubMed: 11352587] http://dx.doi.org/10.1006/jmbi.2001.4623
	Suh JY, Tang C, Cai M, Clore GM. Visualization of the phosphorylated active site loop of the cytoplasmic B domain of the mannitol transporter II(Mannitol) of the Escherichia coli phosphotransferase system by NMR spectroscopy and residual dipolar couplings. J. Mol. Biol. 353 2005 1129-36 [PubMed: 16219324] http://dx.doi.org/10.1016/j.jmb.2005.09.033
	Suh JY, Cai M, Williams DC Jr, Clore GM. Solution structure of a post-transition state analog of the phosphotransfer reaction between the A and B cytoplasmic domains of the mannitol transporter IIMannitol of the Escherichia coli phosphotransferase system. J. Biol. Chem. 281 2006 8939-49 [PubMed: 16443929] http://dx.doi.org/10.1074/jbc.M513466200
	Ab E, Schuurman-Wolters G, Reizer J, Saier MH, Dijkstra K, Scheek RM, Robillard GT. The NMR side-chain assignments and solution structure of enzyme IIBcellobiose of the phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. Protein Sci. 6 1997 304-14 [PubMed: 9041631] http://www.proteinscience.org/cgi/content/abstract/6/2/304
	van Montfort RL, Pijning T, Kalk KH, Reizer J, Saier MH Jr, Thunnissen MM, Robillard GT, Dijkstra BW. The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases. Structure 5 1997 217-25 [PubMed: 9032081] http://dx.doi.org/10.1016/S0969-2126(97)00180-9

InterPro 23.1