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InterPro: IPR003343 Bacterial Ig-like, group 2

Protein matches Help

UniProtKB

Matches:

1734 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003343 Big_2

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02368	Big_2	1706
SMART	SM00635	BID_2	1358
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003535 Intimin bacterial adhesion mediator protein
IPR008964 Invasin/intimin cell-adhesion
IPR017312 Peptidase S8A, subtilisin-related, shewanella-2

InterPro annotation

Entry Details in BioMart

Abstract

Proteins that contain this domain are found in a variety of bacterial and phage surface proteins such as intimins. Intimin is a bacterial cell-adhesion molecule that mediates the intimate bacterial host-cell interaction. It contains three domains; two immunoglobulin-like domains and a C-type lectin-like module implying that carbohydrate recognition may be important in intimin-mediated cell adhesion [1].

Structural links Help

PDB - click here

SCOP: b.1.14.1

CATH: 2.60.40.1080

Database links Help

PANDIT: PF02368

Blocks: IPB003343

Pfam Clan: CL0159.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003343

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P03733 Major tail protein V

P11654 Nuclear pore membrane glycoprotein 210

P19809 Intimin

Q5VU65 Nuclear pore membrane glycoprotein 210-like

Q9D2F7 Nuclear pore membrane glycoprotein 210-like

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003535	Intimin bacterial adhesion mediator protein
IPR016187	C-type lectin fold
IPR016186	C-type lectin-like
IPR008964	Invasin/intimin cell-adhesion
IPR003343	Bacterial Ig-like, group 2
IPR013117	Intimin, C-terminal
IPR003344	Bacterial Ig-like, group 1
IPR002482	Peptidoglycan-binding Lysin subgroup
IPR018392	Peptidoglycan-binding lysin domain
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Kelly G, Prasannan S, Daniell S, Fleming K, Frankel G, Dougan G, Connerton I, Matthews S. Structure of the cell-adhesion fragment of intimin from enteropathogenic Escherichia coli. Nat. Struct. Biol. 6 313-8 1999 [PubMed: 10201396] http://dx.doi.org/10.1038/7545

Additional Reading Open in usermanual
	Luo Y, Frey EA, Pfuetzner RA, Creagh AL, Knoechel DG, Haynes CA, Finlay BB, Strynadka NC. Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Nature 405 2000 1073-7 [PubMed: 10890451] http://dx.doi.org/10.1038/35016618
	Batchelor M, Prasannan S, Daniell S, Reece S, Connerton I, Bloomberg G, Dougan G, Frankel G, Matthews S. Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli. EMBO J. 19 2000 2452-64 [PubMed: 10835344] http://dx.doi.org/10.1093/emboj/19.11.2452

InterPro 23.1