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InterPro: IPR003318 Glycoside hydrolase, family 70, catalytic core

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UniProtKB

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107 proteins

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Accession

IPR003318 Glyco_hydro70cat

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02324	Glyco_hydro_70	107
Signatures in BioMart

InterPro Relationships Help

Contains

IPR013781 Glycoside hydrolase, subgroup, catalytic core

GO Term annotation Help

Process

GO:0009250 glucan biosynthetic process

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) (EC:2.4.1.5, GH70) catalyse the transfer of D-glucopyramnosyl units from sucrose onto acceptor molecules [5]. This signature roughly corresponds to the N-terminal catalytic domain of the enzyme. Members of this group also contain the putative cell wall binding repeat (IPR002479).

Database links Help

Enzyme: EC:2.4.1.5

CAZy: GH70

PANDIT: PF02324

Blocks: IPB003318

Pfam Clan: CL0058.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003318

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P08987 Glucosyltransferase-I

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002479	Putative cell wall binding repeat
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR003318	Glycoside hydrolase, family 70, catalytic core
IPR017853	Glycoside hydrolase, catalytic core
IPR018337	Cell wall/choline-binding repeat
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999
5.	Monchois V, Willemot RM, Remaud-Simeon M, Croux C, Monsan P. Cloning and sequencing of a gene coding for a novel dextransucrase from Leuconostoc mesenteroides NRRL B-1299 synthesizing only alpha (1-6) and alpha (1-3) linkages. Gene 182 23-32 1996 [PubMed: 8982063] http://dx.doi.org/10.1016/S0378-1119(96)00443-X

Additional Reading Open in usermanual
	Henrissat B. A classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem. J. 280 ( Pt 2) 1991 309-16 [PubMed: 1747104] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=1747104

InterPro 23.1