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InterPro: IPR003251 Rubrerythrin

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1549 proteins

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Accession

IPR003251 Rubrerythrin

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02915	Rubrerythrin	1549
Signatures in BioMart

InterPro Relationships Help

Found in

IPR009040 Ferritin-like
IPR015838 Uncharacterised protein family, rubrerythrin domain-containing
IPR017040 Uncharacterised conserved protein UCP035918 , Rubrerythrin-related protein, DUF125 domain-containing

Contains

IPR012347 Ferritin-related

GO Term annotation Help

Function

GO:0046872 metal ion binding

InterPro annotation

Entry Details in BioMart

Abstract

Rubrerythrin (Rr), found in anaerobic sulphate-reducing bacteria [1], is a fusion protein containing an N-terminal diiron-binding domain and a C-terminal domain homologous to rubredoxin [2]. The physiological role of Rr has not been identified.

The 3-D structure of Desulphovibrio vulgaris rubrerythrin has been solved [3]. The structure reveals a tetramer of two-domain subunits. In each monomer, the N-terminal 146 residues form a four-alpha-helix bundle containing the diiron-oxo site (centre I), and the C-terminal 45 residues form a rubredoxin-like FeS4 domain.

Structural links Help

PDB - click here

SCOP: a.25.1.1

CATH: 1.20.1260.10

Database links Help

Enzyme: EC:1.14.13.81

PANDIT: PF02915

Blocks: IPB003251

COMe: PRX000046

Pfam Clan: CL0044.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003251

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O28043 Uncharacterized protein AF_2240

P24931 Rubrerythrin

P48329 Uncharacterized protein in petA-psaM intergenic region

P72584 Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1

Q9M591 Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR009040	Ferritin-like
IPR008434	Magnesium-protoporphyrin IX monomethyl ester aerobic oxidative cyclase
IPR009078	Ferritin/ribonucleotide reductase-like
IPR012347	Ferritin-related
IPR003251	Rubrerythrin
IPR004039	Rubredoxin-type Fe(Cys)4 protein
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Moura I, Tavares P, Ravi N. Characterization of three proteins containing multiple iron sites: rubrerythrin, desulfoferrodoxin, and a protein containing a six-iron cluster. Meth. Enzymol. 243 216-40 1994 [PubMed: 7830612] http://dx.doi.org/10.1016/0076-6879(94)43017-9
2.	Van Beeumen JJ, Van Driessche G, Liu MY, LeGall J. The primary structure of rubrerythrin, a protein with inorganic pyrophosphatase activity from Desulfovibrio vulgaris. Comparison with hemerythrin and rubredoxin. J. Biol. Chem. 266 20645-53 1991 [PubMed: 1657933] http://intl.jbc.org/cgi/reprint/266/31/20645.pdf
3.	deMare F, Kurtz DM Jr, Nordlund P. The structure of Desulfovibrio vulgaris rubrerythrin reveals a unique combination of rubredoxin-like FeS4 and ferritin-like diiron domains. Nat. Struct. Biol. 3 539-46 1996 [PubMed: 8646540] http://dx.doi.org/10.1038/nsb0696-539

Additional Reading Open in usermanual
	Iyer RB, Silaghi-Dumitrescu R, Kurtz DM Jr, Lanzilotta WN. High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins. J. Biol. Inorg. Chem. 10 2005 407-16 [PubMed: 15895271] http://dx.doi.org/10.1007/s00775-005-0650-8
	Jin S, Kurtz DM Jr, Liu ZJ, Rose J, Wang BC. X-ray crystal structure of Desulfovibrio vulgaris rubrerythrin with zinc substituted into the [Fe(SCys)4] site and alternative diiron site structures. Biochemistry 43 2004 3204-13 [PubMed: 15023070] http://dx.doi.org/10.1021/bi0356193
	Fushinobu S, Shoun H, Wakagi T. Crystal structure of sulerythrin, a rubrerythrin-like protein from a strictly aerobic archaeon, Sulfolobus tokodaii strain 7, shows unexpected domain swapping. Biochemistry 42 2003 11707-15 [PubMed: 14529281] http://dx.doi.org/10.1021/bi034220b
	Jin S, Kurtz DM Jr, Liu ZJ, Rose J, Wang BC. Displacement of iron by zinc at the diiron site of Desulfovibrio vulgaris rubrerythrin: X-ray crystal structure and anomalous scattering analysis. J. Inorg. Biochem. 98 2004 786-96 [PubMed: 15134924] http://dx.doi.org/10.1016/j.jinorgbio.2004.01.005
	Tempel W, Liu ZJ, Schubot FD, Shah A, Weinberg MV, Jenney FE Jr, Arendall WB 3rd, Adams MW, Richardson JS, Richardson DC, Rose JP, Wang BC. Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. Proteins 57 2004 878-82 [PubMed: 15468318] http://dx.doi.org/10.1002/prot.20280

InterPro 23.1