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InterPro: IPR003156 Phosphoesterase, DHHA1

Protein matches Help

UniProtKB

Matches:

5287 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003156 Pesterase_DHHA1

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02272	DHHA1	5287
Signatures in BioMart

InterPro Relationships Help

Found in

IPR002318 Alanyl-tRNA synthetase, class IIc
IPR004610 Bacterial RecJ exonuclease
IPR014528 Signal transduction phosphoesterase predicted, YybT type

GO Term annotation Help

Function

GO:0003676 nucleic acid binding

InterPro annotation

Entry Details in BioMart

Abstract

This domain is often found adjacent to the DHH domain, found in the RecJ-like phosphoesterase family IPR001667, and is called DHHA1 for DHH associated domain. DHHA1 is diagnostic of DHH subfamily 1 members [1]. This domain is also found in alanyl tRNA synthetase e.g. P00957, suggesting that it may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.

Structural links Help

PDB - click here

SCOP: c.107.1.2

Database links Help

Enzyme: EC:6.1.1.7

PANDIT: PF02272

Blocks: IPB003156

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR003156

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P36428 Alanyl-tRNA synthetase, mitochondrial

P40825 Alanyl-tRNA synthetase, cytoplasmic

P49588 Alanyl-tRNA synthetase, cytoplasmic

P74423 Alanyl-tRNA synthetase

Q8BGQ7 Alanyl-tRNA synthetase, cytoplasmic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012947	Threonyl/alanyl tRNA synthetase, SAD
IPR002318	Alanyl-tRNA synthetase, class IIc
IPR018165	Alanyl-tRNA synthetase, class IIc, core domain
IPR003156	Phosphoesterase, DHHA1
IPR018162	Alanyl-tRNA synthetase, class IIc, anti-codon-binding domain
IPR018163	Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164	Alanyl-tRNA synthetase, class IIc, N-terminal
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Aravind L, Koonin EV. A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem. Sci. 23 17-9 1998 [PubMed: 9478130] http://dx.doi.org/10.1016/S0968-0004(97)01162-6

Additional Reading Open in usermanual
	Yamagata A, Kakuta Y, Masui R, Fukuyama K. The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Proc. Natl. Acad. Sci. U.S.A. 99 2002 5908-12 [PubMed: 11972066] http://dx.doi.org/10.1073/pnas.092547099

InterPro 23.1