EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR003038 Defender against death DAD protein

Protein matches Help

UniProtKB

Matches:

186 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR003038 DAD

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02109	DAD	184
PIRSF	PIRSF005588	DAD	162
PANTHER	PTHR10705	DAD	181
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family are thought to be integral membrane proteins. Some members of this family have been shown to cause apoptosis if mutated [1], these proteins are known as DAD for defender against death. The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation [2].

Database links Help

PANDIT: PF02109

Blocks: IPB003038

Taxonomic coverage Help

Example proteins Help

P46964 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2

P52872 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1

P61803 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

P61804 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Q9VLM5 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003038	Defender against death DAD protein
	ModBase

Publications Open in usermanual
1.	Nakashima T, Sekiguchi T, Kuraoka A, Fukushima K, Shibata Y, Komiyama S, Nishimoto T. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol. Cell. Biol. 13 6367-74 1993 [PubMed: 8413235] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=8413235&action=stream&blobtype=pdf
2.	Silberstein S, Collins PG, Kelleher DJ, Gilmore R. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. J. Cell Biol. 131 371-83 1995 [PubMed: 7593165] http://dx.doi.org/10.1083/jcb.131.2.371

InterPro 23.1