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InterPro: IPR002909 Cell surface receptor IPT/TIG

Protein matches Help

UniProtKB

Matches:

1410 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002909 IPT_TIG_rcpt

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01833	TIG	1392
SMART	SM00429	IPT	817
Signatures in BioMart

InterPro Relationships Help

Parent

IPR014756 Immunoglobulin E-set

Found in

IPR000451 NF-kappa-B/Rel/dorsal
IPR003523 Transcription factor COE
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR011363 Dorsal protein
IPR013783 Immunoglobulin-like fold
IPR015646 Nuclear factor of activated T-cells 5
IPR015647 Nuclear factor of activated T-cells 1
IPR015716 CD2 adhesion molecule
IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
IPR018286 Nuclear factor of activated T cells (NFAT), subgroup
IPR020707 Tyrosine-protein kinase, hepatocyte growth factor receptor
IPR020739 Tyrosine-protein kinase, MSP receptor

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering) [1].

Structural links Help

PDB - click here

SCOP: b.1.18.1 , b.1.18.18 , b.1.18.2 , b.2.5.3 , g.16.2.1

CATH: 2.60.40.10

Database links Help

PANDIT: PF01833

Blocks: IPB002909

Interactions Help

This domain has been experimentally proven to be involved in Protein:Protein interactions.
Representative data is shown with the following example proteins:

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002909

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O43157 Plexin-B1

O45657 Plexin-2

P15330 Embryonic polarity protein dorsal

P25799 Nuclear factor NF-kappa-B p105 subunit

P35210 Protein SPT23

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013783	Immunoglobulin-like fold
IPR000451	NF-kappa-B/Rel/dorsal
IPR000488	Death
IPR002165	Plexin
IPR020683	Ankyrin repeat-containing domain
IPR014756	Immunoglobulin E-set
IPR008936	Rho GTPase activation protein
IPR013548	Plexin, cytoplasmic RasGAP domain
IPR002909	Cell surface receptor IPT/TIG
IPR016201	Plexin-like fold
IPR011029	DEATH-like
IPR001627	Semaphorin/CD100 antigen
IPR008967	p53-like transcription factor, DNA-binding
IPR003659	Plexin/semaphorin/integrin
IPR002110	Ankyrin repeat
IPR015716	CD2 adhesion molecule
IPR011539	Rel homology
IPR015943	WD40/YVTN repeat-like-containing domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Collesi C, Santoro MM, Gaudino G, Comoglio PM. A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol. Cell. Biol. 16 5518-26 1996 [PubMed: 8816464] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8816464

Additional Reading Open in usermanual
	Panne D, Maniatis T, Harrison SC. An atomic model of the interferon-beta enhanceosome. Cell 129 2007 1111-23 [PubMed: 17574024] http://dx.doi.org/10.1016/j.cell.2007.05.019
	Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG. LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 2007 239-51 [PubMed: 17785205] http://dx.doi.org/10.1016/j.ccr.2007.07.002
	Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G. X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J. Mol. Biol. 373 2007 723-34 [PubMed: 17869269] http://dx.doi.org/10.1016/j.jmb.2007.08.039
	Niemann HH, Jager V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW. Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. Cell 130 2007 235-46 [PubMed: 17662939] http://dx.doi.org/10.1016/j.cell.2007.05.037
	Bork P, Doerks T, Springer TA, Snel B. Domains in plexins: links to integrins and transcription factors. Trends Biochem. Sci. 24 1999 261-3 [PubMed: 10390613] http://dx.doi.org/10.1016/S0968-0004(99)01416-4
	Bates DL, Barthel KK, Wu Y, Kalhor R, Stroud JC, Giffin MJ, Chen L. Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element. Structure 16 2008 684-94 [PubMed: 18462673] http://dx.doi.org/10.1016/j.str.2008.01.020
	Kelly RM, Leemhuis H, Rozeboom HJ, van Oosterwijk N, Dijkstra BW, Dijkhuizen L. Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution. Biochem. J. 413 2008 517-25 [PubMed: 18422488] http://dx.doi.org/10.1042/BJ20080353
	Friedmann DR, Wilson JJ, Kovall RA. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. J. Biol. Chem. 283 2008 14781-91 [PubMed: 18381292] http://dx.doi.org/10.1074/jbc.M709501200
	Aravind L, Koonin EV. Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. J. Mol. Biol. 287 1999 1023-40 [PubMed: 10222208] http://dx.doi.org/10.1006/jmbi.1999.2653

InterPro 23.1