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InterPro: IPR002773 Deoxyhypusine synthase

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508 proteins

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Accession List
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Accession

IPR002773 Deoxyhypus_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.40.910.10	Deoxyhypus_synth	496
Pfam	PF01916	DS	508
PANTHER	PTHR11703	Deoxyhypus_synth	502
TIGRFAMs	TIGR00321	dhys	235
Signatures in BioMart

GO Term annotation Help

Process

GO:0008612 peptidyl-lysine modification to hypusine

InterPro annotation

Entry Details in BioMart

Abstract

Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see IPR001884), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) EC:2.5.1.46. The enzyme catalyses the following reaction:

Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine

The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [1]. The structure is known for this enzyme [1] in complex with its NAD⁺ cofactor.

Structural links Help

PDB - click here

SCOP: c.31.1.1

CATH: 3.40.910.10

Database links Help

Enzyme: EC:2.5.1.46

PANDIT: PF01916

Blocks: IPB002773

Pfam Clan: CL0085.10

Taxonomic coverage Help

Example proteins Help

P38791 Deoxyhypusine synthase

P49366 Deoxyhypusine synthase

Q3TXU5 Deoxyhypusine synthase

Q9VSF4 Probable deoxyhypusine synthase

Q9XXJ0 Probable deoxyhypusine synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002773	Deoxyhypusine synthase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Liao DI, Wolff EC, Park MH, Davies DR. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Structure 6 23-32 1998 [PubMed: 9493264] http://dx.doi.org/10.1016/S0969-2126(98)00004-5

Additional Reading Open in usermanual
	Umland TC, Wolff EC, Park MH, Davies DR. A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex. J. Biol. Chem. 279 2004 28697-705 [PubMed: 15100216] http://dx.doi.org/10.1074/jbc.M404095200

InterPro 23.1