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InterPro: IPR002759 Ribonuclease P-related

Protein matches Help

UniProtKB

Matches:

223 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002759 RNase_P_related

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01900	RNase_P_Rpp14	223
Signatures in BioMart

InterPro Relationships Help

Children

IPR016434 Ribonuclease P, protein component 2
IPR016819 Ribonuclease P/MRP protein, subunit Pop5

GO Term annotation Help

Process

GO:0008033 tRNA processing

Function

GO:0004540 ribonuclease activity

InterPro annotation

Entry Details in BioMart

Abstract

This family contains proteins found in some eukaryotes and archaebacteria that are related to yeast ribonuclease P. This enzyme is essential for tRNA processing generating 5'-termini of mature tRNA molecules [1]. tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14, Rpp20, Rpp25, Rpp29, Rpp30, Rpp38, and Rpp40 [2].

Structural links Help

PDB - click here

SCOP: d.58.59.1

Database links Help

Enzyme: EC:3.1.26.5

PANDIT: PF01900

Blocks: IPB002759

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002759

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O95059 Ribonuclease P protein subunit p14

P28005 Ribonucleases P/MRP protein subunit POP5

Q1JQ92 Ribonuclease P/MRP protein subunit POP5

Q6AWV1 Probable ribonuclease P/MRP protein subunit POP5

Q9CQH8 Ribonuclease P protein subunit p14

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016819	Ribonuclease P/MRP protein, subunit Pop5
IPR002759	Ribonuclease P-related
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Bussey H, Kaback DB, Zhong W, Vo DT, Clark MW, Fortin N, Hall J, Ouellette BF, Keng T, Barton AB. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 92 3809-13 1995 [PubMed: 7731988] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=7731988
2.	Jarrous N, Eder PS, Wesolowski D, Altman S. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. RNA 5 153-7 1999 [PubMed: 10024167] http://dx.doi.org/10.1017/S135583829800185X

Additional Reading Open in usermanual
	Kawano S, Nakashima T, Kakuta Y, Tanaka I, Kimura M. Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme. J. Mol. Biol. 357 2006 583-91 [PubMed: 16430919] http://dx.doi.org/10.1016/j.jmb.2005.12.086
	Wilson RC, Bohlen CJ, Foster MP, Bell CE. Structure of Pfu Pop5, an archaeal RNase P protein. Proc. Natl. Acad. Sci. U.S.A. 103 2006 873-8 [PubMed: 16418270] http://dx.doi.org/10.1073/pnas.0508004103

InterPro 23.1