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InterPro: IPR002724 Pyruvoyl-dependent arginine decarboxylase

Protein matches Help

UniProtKB

Matches:

125 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002724 Pyruvoyl-dep_arg_deCO2ase

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_01404	Pyruvoyl-dep_arg_deCO2ase	81
ProDom	PD010449	Pyruvoyl-dep_arg_deCO2ase	123
Pfam	PF01862	PvlArgDC	124
PIRSF	PIRSF005216	Pyruvoyl-dep_arg_deCO2ase	87
TIGRFAMs	TIGR00286	PvlArgDC	85
Signatures in BioMart

InterPro Relationships Help

Parent

IPR016104 Pyruvoyl-dependent histidine/arginine decarboxylase

Contains

IPR016105 Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain

GO Term annotation Help

Process

GO:0006527 arginine catabolic process

Function

GO:0008792 arginine decarboxylase activity

InterPro annotation

Entry Details in BioMart

Abstract

Arginine decarboxylase (EC:4.1.1.19) catalyses the interconversion of arginine and agmatine plus carbon dioxide [1]. It requires a pyruvoyl group for its activity. Archaeoglobus fulgidus contains three copies of this 80-residue domain, all of which are very closely related.

Structural links Help

PDB - click here

SCOP: d.155.1.2

CATH: 3.30.60.30 , 3.50.20.10

Database links Help

Enzyme: EC:4.1.1.19

PANDIT: PF01862

Blocks: IPB002724

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002724

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A4SFG2 Probable pyruvoyl-dependent arginine decarboxylase

Q57764 Pyruvoyl-dependent arginine decarboxylase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002724	Pyruvoyl-dependent arginine decarboxylase
IPR016105	Pyruvoyl-dependent histidine/arginine decarboxylase, 3-layer sandwich domain
IPR016104	Pyruvoyl-dependent histidine/arginine decarboxylase
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Tolbert WD, Graham DE, White RH, Ealick SE. Pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii: crystal structures of the self-cleaved and S53A proenzyme forms. Structure 11 285-94 2003 [PubMed: 12623016] http://dx.doi.org/10.1016/S0969-2126(03)00026-1

Additional Reading Open in usermanual
	Graham DE, Xu H, White RH. Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis. J. Biol. Chem. 277 2002 23500-7 [PubMed: 11980912] http://dx.doi.org/10.1074/jbc.M203467200
	Soriano EV, McCloskey DE, Kinsland C, Pegg AE, Ealick SE. Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii. Acta Crystallogr. D Biol. Crystallogr. 64 2008 377-82 [PubMed: 18391404] http://dx.doi.org/10.1107/S0907444908000474

InterPro 23.1