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InterPro: IPR002618 UTP--glucose-1-phosphate uridylyltransferase

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702 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
Matches in BioMart

Accession

IPR002618 UDPGP_trans

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01704	UDPGP	627
PANTHER	PTHR11952	UDPGP_trans	690
Signatures in BioMart

InterPro Relationships Help

Children

IPR016267 UTP--glucose-1-phosphate uridylyltransferase, subgroup

GO Term annotation Help

Process

GO:0008152 metabolic process

Function

GO:0016779 nucleotidyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of UTP--glucose-1-phosphate uridylyltransferases (EC:2.7.7.9). Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPP_i [1]. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type [1]. In Dictyostelium discoideum (Slime mold), mutants in this enzyme abort the development cycle [2]. Also within this family is UDP-N-acetylglucosamine pyrophosphorylase (Q16222) [3] and two hypothetical proteins from Borrelia burgdorferi, the Lyme disease spirochaete (O51893 and O51036).

Structural links Help

PDB - click here

SCOP: b.81.1.4 , c.68.1.5

CATH: 3.90.550.10

Database links Help

Enzyme: EC:2.7.7

PANDIT: PF01704

Blocks: IPB002618

Pfam Clan: CL0110.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002618

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P32861 UTP--glucose-1-phosphate uridylyltransferase

Q16222 UDP-N-acetylhexosamine pyrophosphorylase

Q18493 Probable UDP-N-acetylglucosamine pyrophosphorylase

Q91YN5 UDP-N-acetylhexosamine pyrophosphorylase

Q9M9P3 Probable UTP--glucose-1-phosphate uridylyltransferase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002618	UTP--glucose-1-phosphate uridylyltransferase
IPR016267	UTP--glucose-1-phosphate uridylyltransferase, subgroup
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Duggleby RG, Chao YC, Huang JG, Peng HL, Chang HY. Sequence differences between human muscle and liver cDNAs for UDPglucose pyrophosphorylase and kinetic properties of the recombinant enzymes expressed in Escherichia coli. Eur. J. Biochem. 235 173-9 1996 [PubMed: 8631325] http://dx.doi.org/10.1111/j.1432-1033.1996.00173.x
2.	Ragheb JA, Dottin RP. Structure and sequence of a UDP glucose pyrophosphorylase gene of Dictyostelium discoideum. Nucleic Acids Res. 15 3891-906 1987 [PubMed: 3035502] http://dx.doi.org/10.1093/nar/15.9.3891
3.	Mio T, Yabe T, Arisawa M, Yamada-Okabe H. The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. J. Biol. Chem. 273 14392-7 1998 [PubMed: 9603950] http://dx.doi.org/10.1074/jbc.273.23.14392

Additional Reading Open in usermanual
	Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr. Ensemble refinement of protein crystal structures: validation and application. Structure 15 2007 1040-52 [PubMed: 17850744] http://dx.doi.org/10.1016/j.str.2007.06.019
	Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y. Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. EMBO J. 20 2001 6191-202 [PubMed: 11707391] http://dx.doi.org/10.1093/emboj/20.22.6191
	Maruyama D, Nishitani Y, Nonaka T, Kita A, Fukami TA, Mio T, Yamada-Okabe H, Yamada-Okabe T, Miki K. Crystal structure of uridine-diphospho-N-acetylglucosamine pyrophosphorylase from Candida albicans and catalytic reaction mechanism. J. Biol. Chem. 282 2007 17221-30 [PubMed: 17392279] http://dx.doi.org/10.1074/jbc.M611873200
	McCoy JG, Bitto E, Bingman CA, Wesenberg GE, Bannen RM, Kondrashov DA, Phillips GN Jr. Structure and dynamics of UDP-glucose pyrophosphorylase from Arabidopsis thaliana with bound UDP-glucose and UTP. J. Mol. Biol. 366 2007 830-41 [PubMed: 17178129] http://dx.doi.org/10.1016/j.jmb.2006.11.059

InterPro 23.1