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InterPro: IPR002582 Holo-[acyl carrier protein] synthase

Protein matches Help

UniProtKB

Matches:

1236 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002582 ACPS

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR00516	acpS	1236
Signatures in BioMart

InterPro Relationships Help

Parent

IPR004568 Phosphopantethiene-protein transferase

GO Term annotation Help

Process

GO:0006633 fatty acid biosynthetic process

Function

GO:0000287 magnesium ion binding
GO:0008897 holo-[acyl-carrier-protein] synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

Holo-acyl carrier protein synthase (ACPS) transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to Ser-36 of acyl carrier protein (ACP) in Escherichia coli. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1].

Structural links Help

PDB - click here

SCOP: d.150.1.2

CATH: 3.90.470.20

Database links Help

Enzyme: EC:2.7.8.7

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002582

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O86785 Holo-[acyl-carrier-protein] synthase

Q7NE72 Holo-[acyl-carrier-protein] synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR004568	Phosphopantethiene-protein transferase
IPR002582	Holo-[acyl carrier protein] synthase
IPR008278	4'-phosphopantetheinyl transferase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Open in usermanual
1.	Lambalot RH, Walsh CT. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270 24658-61 1995 [PubMed: 7559576] http://dx.doi.org/10.1074/jbc.270.42.24658

Additional Reading Open in usermanual
	Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure 8 2000 883-95 [PubMed: 10997907] http://dx.doi.org/10.1016/S0969-2126(00)00178-7
	Chirgadze NY, Briggs SL, McAllister KA, Fischl AS, Zhao G. Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis. EMBO J. 19 2000 5281-7 [PubMed: 11032795] http://dx.doi.org/10.1093/emboj/19.20.5281

InterPro 23.1