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InterPro: IPR002545 CheW-like protein

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UniProtKB

Matches:

4724 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002545 CheW

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01584	CheW	4704
PROSITE profile	PS50851	CHEW	4604
SMART	SM00260	CheW	4636
SuperFamily	SSF50341	CheW	4680
Signatures in BioMart

InterPro Relationships Help

Found in

IPR014506 Uncharacterised conserved protein UCP020479, signal transduction CheW-like

GO Term annotation Help

Process

GO:0006935 chemotaxis
GO:0007165 signal transduction

Function

GO:0004871 signal transducer activity

Component

GO:0005622 intracellular

InterPro annotation

Entry Details in BioMart

Abstract

CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flagellar rotation. This family includes CheW and other related proteins that are involved in chemotaxis. The CheW-like regulatory domain in CheA [1] binds to CheW, suggesting that these domains can interact with each other.

Structural links Help

PDB - click here

SCOP: b.40.7.1 , d.122.1.3

CATH: 2.30.30.40 , 2.40.50.180 , 3.30.565.10

Database links Help

PROSITE doc: PDOC50851

PANDIT: PF01584

Blocks: IPB002545

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002545

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P07363 Chemotaxis protein cheA

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005467	Signal transduction histidine kinase, core
IPR003594	ATPase-like, ATP-binding domain
IPR002545	CheW-like protein
IPR004105	Signal transduction histidine kinase, subgroup, homodimeric
IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain
IPR009082	Signal transduction histidine kinase, homodimeric
IPR004358	Signal transduction histidine kinase-related protein, C-terminal
IPR015162	CheY binding
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Bilwes AM, Alex LA, Crane BR, Simon MI. Structure of CheA, a signal-transducing histidine kinase. Cell 96 131-41 1999 [PubMed: 9989504] http://dx.doi.org/10.1016/S0092-8674(00)80966-6

Additional Reading Open in usermanual
	Bilwes AM, Quezada CM, Croal LR, Crane BR, Simon MI. Nucleotide binding by the histidine kinase CheA. Nat. Struct. Biol. 8 2001 353-60 [PubMed: 11276258] http://dx.doi.org/10.1038/86243
	Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW. The solution structure and interactions of CheW from Thermotoga maritima. Nat. Struct. Biol. 9 2002 121-5 [PubMed: 11799399] http://dx.doi.org/10.1038/nsb753
	Alexandre G, Zhulin IB. Different evolutionary constraints on chemotaxis proteins CheW and CheY revealed by heterologous expression studies and protein sequence analysis. J. Bacteriol. 185 2003 544-52 [PubMed: 12511501] http://dx.doi.org/10.1128/JB.185.2.544-552.2003
	Park SY, Borbat PP, Gonzalez-Bonet G, Bhatnagar J, Pollard AM, Freed JH, Bilwes AM, Crane BR. Reconstruction of the chemotaxis receptor-kinase assembly. Nat. Struct. Mol. Biol. 13 2006 400-7 [PubMed: 16622408] http://dx.doi.org/10.1038/nsmb1085
	Karatan E, Saulmon MM, Bunn MW, Ordal GW. Phosphorylation of the response regulator CheV is required for adaptation to attractants during Bacillus subtilis chemotaxis. J. Biol. Chem. 276 2001 43618-26 [PubMed: 11553614] http://dx.doi.org/10.1074/jbc.M104955200

InterPro 23.1