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InterPro: IPR002504 ATP-NAD/AcoX kinase

Protein matches Help

UniProtKB

Matches:

2513 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002504 ATP_NADK

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01513	NAD_kinase	2488
PANTHER	PTHR20275	ATP_NADK	2285
Signatures in BioMart

InterPro Relationships Help

Children

IPR011386 ATP-NAD kinase
IPR011391 Acetoin catabolism kinase AcoX

Contains

IPR016064 ATP-NAD kinase, PpnK-type
IPR017437 ATP-NAD kinase, PpnK-type, all-beta
IPR017438 ATP-NAD kinase, PpnK-type, alpha/beta

GO Term annotation Help

Process

GO:0008152 metabolic process

Function

GO:0003951 NAD+ kinase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family are ATP-NAD kinases EC:2.7.1.23. The enzymes catalyse the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus.

Structural links Help

PDB - click here

SCOP: e.52.1.1

CATH: 2.60.200.30 , 3.40.50.10330

Database links Help

Enzyme: EC:2.7.1.23

PANDIT: PF01513

Blocks: IPB002504

Pfam Clan: CL0240.4

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002504

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O95544 NAD kinase

P21373 NAD(+) kinase

P58058 NAD kinase

Q500Y9 NADH kinase

Q53NI2 Probable NAD kinase 2, chloroplastic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017437	ATP-NAD kinase, PpnK-type, all-beta
IPR017438	ATP-NAD kinase, PpnK-type, alpha/beta
IPR002504	ATP-NAD/AcoX kinase
IPR016064	ATP-NAD kinase, PpnK-type
	SWISS-MODEL
	ModBase

Publications Help

Additional Reading Open in usermanual
	Mori S, Yamasaki M, Maruyama Y, Momma K, Kawai S, Hashimoto W, Mikami B, Murata K. NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex. Biochem. Biophys. Res. Commun. 327 2005 500-8 [PubMed: 15629142] http://dx.doi.org/10.1016/j.bbrc.2004.11.163
	Garavaglia S, Raffaelli N, Finaurini L, Magni G, Rizzi M. A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis. J. Biol. Chem. 279 2004 40980-6 [PubMed: 15269221] http://dx.doi.org/10.1074/jbc.M406586200
	Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP. J. Mol. Biol. 354 2005 289-303 [PubMed: 16242716] http://dx.doi.org/10.1016/j.jmb.2005.09.026

InterPro 23.1