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InterPro: IPR002502 N-acetylmuramoyl-L-alanine amidase, family 2

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UniProtKB

Matches:

3238 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002502 Amidase_2

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.40.80.10	Amidase_2	2572
Pfam	PF01510	Amidase_2	3120
SMART	SM00644	Ami_2	2618
SuperFamily	SSF55846	Amidase_2	3064
Signatures in BioMart

InterPro Relationships Help

Children

IPR015510 Peptidoglycan recognition protein

GO Term annotation Help

Process

GO:0009253 peptidoglycan catabolic process

Function

GO:0008745 N-acetylmuramoyl-L-alanine amidase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28 This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The structure is known for the Bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.

Structural links Help

PDB - click here

SCOP: d.118.1.1

CATH: 3.40.80.10

Database links Help

PANDIT: PF01510

Blocks: IPB002502

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002502

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A1A547 Peptidoglycan recognition protein I-alpha

O75594 Peptidoglycan recognition protein

P00806 N-acetylmuramoyl-L-alanine amidase

P06653 Autolysin

Q8INK6 Peptidoglycan-recognition protein LB

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002502	N-acetylmuramoyl-L-alanine amidase, family 2
IPR006619	Peptidoglycan recognition protein, metazoa/bacteria
IPR002479	Putative cell wall binding repeat
IPR015510	Peptidoglycan recognition protein
IPR018337	Cell wall/choline-binding repeat
IPR017331	Peptidoglycan recognition protein, PGRP-S
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci. 15 2006 1199-206 [PubMed: 16641493] http://dx.doi.org/10.1110/ps.062077606
	Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, Aggarwal K, Goldman WE, Silverman N, Kurata S, Oh BH. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. J. Biol. Chem. 281 2006 8286-95 [PubMed: 16428381] http://dx.doi.org/10.1074/jbc.M513030200
	Guan R, Wang Q, Sundberg EJ, Mariuzza RA. Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. J. Mol. Biol. 347 2005 683-91 [PubMed: 15769462] http://dx.doi.org/10.1016/j.jmb.2005.01.070
	Wang X, Wilkinson BJ, Jayaswal RK. Sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity. Gene 102 1991 105-9 [PubMed: 1677905] http://dx.doi.org/10.1016/0378-1119(91)90547-O
	Chang CI, Ihara K, Chelliah Y, Mengin-Lecreulx D, Wakatsuki S, Deisenhofer J. Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Proc. Natl. Acad. Sci. U.S.A. 102 2005 10279-84 [PubMed: 16006509] http://dx.doi.org/10.1073/pnas.0504547102
	Cheng X, Zhang X, Pflugrath JW, Studier FW. The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase. Proc. Natl. Acad. Sci. U.S.A. 91 1994 4034-8 [PubMed: 8171031] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=8171031&action=stream&blobtype=pdf
	Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science 311 2006 1761-4 [PubMed: 16556841] http://dx.doi.org/10.1126/science.1123056
	Potvin C, Leclerc D, Tremblay G, Asselin A, Bellemare G. Cloning, sequencing and expression of a Bacillus bacteriolytic enzyme in Escherichia coli. Mol. Gen. Genet. 214 1988 241-8 [PubMed: 3070348] http://dx.doi.org/10.1007/BF00337717

InterPro 23.1