EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR002496 Phosphoribosyl-AMP cyclohydrolase

Protein matches Help

UniProtKB

Matches:

1525 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002496 PRA_CycHdrlase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
ProDom	PD002610	PRA_CycHdrlase	1523
Pfam	PF01502	PRA-CH	1524
Signatures in BioMart

InterPro Relationships Help

Found in

IPR016298 Histidine biosynthesis trifunctional-protein

GO Term annotation Help

Process

GO:0000105 histidine biosynthetic process

Function

GO:0004635 phosphoribosyl-AMP cyclohydrolase activity

InterPro annotation

Entry Details in BioMart

Abstract

Phosphoribosyl-AMP cyclohydrolase EC:3.5.4.19 catalyses the third step in the histidine biosynthetic pathway:

5-phosphoribosyl-AMP + H₂O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phospho-ribosyl) imidazole-4-carboxamide

It requires Zn²⁺ ions for activity [1].

Structural links Help

PDB - click here

SCOP: b.168.1.1

Database links Help

Enzyme: EC:3.5.4.19

PANDIT: PF01502

Blocks: IPB002496

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002496

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0AG14 Phosphoribosyl-AMP cyclohydrolase

O26347 Phosphoribosyl-AMP cyclohydrolase

O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic

P00815 Histidine biosynthesis trifunctional protein

P74755 Histidine biosynthesis bifunctional protein hisIE

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016298	Histidine biosynthesis trifunctional-protein
IPR008179	Phosphoribosyl-ATP pyrophosphohydrolase
IPR002496	Phosphoribosyl-AMP cyclohydrolase
IPR012131	Histidinol dehydrogenase, prokaryotic-type
IPR016161	Aldehyde/histidinol dehydrogenase
IPR001692	Histidinol dehydrogenase, conserved site
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	D'Ordine RL, Klem TJ, Davisson VJ. N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase: purification and characterization of a unique metalloenzyme. Biochemistry 38 1537-46 1999 [PubMed: 9931020] http://dx.doi.org/10.1021/bi982475x

Additional Reading Open in usermanual
	Sivaraman J, Myers RS, Boju L, Sulea T, Cygler M, Jo Davisson V, Schrag JD. Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI. Biochemistry 44 2005 10071-80 [PubMed: 16042384] http://dx.doi.org/10.1021/bi050472w

InterPro 23.1