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InterPro: IPR002480 DAHP synthetase, class II

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600 proteins

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Accession

IPR002480 DAHP_synth_2

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01474	DAHP_synth_2	599
PANTHER	PTHR21337	DAHP_synth_2	591
TIGRFAMs	TIGR01358	DAHP_synth_II	422
Signatures in BioMart

GO Term annotation Help

Process

GO:0009073 aromatic amino acid family biosynthetic process

Function

GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family (EC:2.5.1.54) catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I (see IPR006218) includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms [1].

The first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). This reaction is catalyzed by DAHP synthase, a metal-activated enzyme, which in microorganisms is the target for negative-feedback regulation by pathway intermediates or by end products.

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SCOP: c.1.10.8

Database links Help

Enzyme: EC:2.5.1.54

PANDIT: PF01474

Blocks: IPB002480

Taxonomic coverage Help

Example proteins Help

A0MH68 Probable phospho-2-dehydro-3-deoxyheptonate aldolase, chloroplastic

P29976 Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic

P80574 Phospho-2-dehydro-3-deoxyheptonate aldolase

P80576 Phospho-2-dehydro-3-deoxyheptonate aldolase

Q75LR2 Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002480	DAHP synthetase, class II
	SWISS-MODEL

Publications Open in usermanual
1.	Walker GE, Dunbar B, Hunter IS, Nimmo HG, Coggins JR. Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa. Microbiology (Reading, Engl.) 142 ( Pt 8) 1973-82 1996 [PubMed: 8760910]

Additional Reading Open in usermanual
	Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ. The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J. Mol. Biol. 354 2005 927-39 [PubMed: 16288916] http://dx.doi.org/10.1016/j.jmb.2005.09.093

InterPro 23.1