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InterPro: IPR002479 Putative cell wall binding repeat

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1483 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR002479 Cell_wall_bd_put

Type

Repeat

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01473	CW_binding_1	1483
Signatures in BioMart

InterPro Relationships Help

Parent

IPR018337 Cell wall/choline-binding repeat

InterPro annotation

Entry Details in BioMart

Abstract

This repeat is found in multiple tandem copies in several proteins. The repeat is 20 amino acid residues long. It has been suggested that these repeats in P15057 might be responsible for the specific recognition of choline-containing cell walls [1]. Similar repeats are found in the glucosyltransferases and glucan-binding protein of oral streptococci, dextransucrases of Leuconostoc mesenteroides as well as toxins of Clostridium difficile [2].

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PDB - click here

SCOP: b.109.1.1

CATH: 2.10.270.10 , 2.20.120.10

Database links Help

PROSITE doc: PDOC51170

PANDIT: PF01473

Blocks: IPB002479

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002479

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O29446 Uncharacterized protein AF_0812

P06653 Autolysin

P15057 Lysozyme

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR018337	Cell wall/choline-binding repeat
IPR002053	Glycoside hydrolase, family 25
IPR002502	N-acetylmuramoyl-L-alanine amidase, family 2
IPR002479	Putative cell wall binding repeat
IPR008270	Glycoside hydrolase, family 25, active site
IPR017853	Glycoside hydrolase, catalytic core
IPR018077	Glycoside hydrolase, family 25 subgroup
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Garcia E, Garcia JL, Garcia P, Arraras A, Sanchez-Puelles JM, Lopez R. Molecular evolution of lytic enzymes of Streptococcus pneumoniae and its bacteriophages. Proc. Natl. Acad. Sci. U.S.A. 85 914-8 1988 [PubMed: 3422470] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=3422470
2.	Shah DS, Joucla G, Remaud-Simeon M, Russell RR. Conserved repeat motifs and glucan binding by glucansucrases of oral streptococci and Leuconostoc mesenteroides. J. Bacteriol. 186 8301-8 2004 [PubMed: 15576779] http://dx.doi.org/10.1128/JB.186.24.8301-8308.2004

Additional Reading Open in usermanual
	Janecek S, Svensson B, Russell RR. Location of repeat elements in glucansucrases of Leuconostoc and Streptococcus species. FEMS Microbiol. Lett. 192 2000 53-7 [PubMed: 11040428] http://dx.doi.org/10.1111/j.1574-6968.2000.tb09358.x
	Banas JA, Russell RR, Ferretti JJ. Sequence analysis of the gene for the glucan-binding protein of Streptococcus mutans Ingbritt. Infect. Immun. 58 1990 667-73 [PubMed: 2307516] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=2307516&action=stream&blobtype=pdf
	Ferretti JJ, Gilpin ML, Russell RR. Nucleotide sequence of a glucosyltransferase gene from Streptococcus sobrinus MFe28. J. Bacteriol. 169 1987 4271-8 [PubMed: 3040686] http://jb.asm.org/cgi/content/abstract/169/9/4271
	Hermoso JA, Lagartera L, Gonzalez A, Stelter M, Garcia P, Martinez-Ripoll M, Garcia JL, Menendez M. Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce. Nat. Struct. Mol. Biol. 12 2005 533-8 [PubMed: 15895092] http://dx.doi.org/10.1038/nsmb940
	Hermoso JA, Monterroso B, Albert A, Galan B, Ahrazem O, Garcia P, Martinez-Ripoll M, Garcia JL, Menendez M. Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1. Structure 11 2003 1239-49 [PubMed: 14527392] http://dx.doi.org/10.1016/j.str.2003.09.005
	Wren BW. A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences. Mol. Microbiol. 5 1991 797-803 [PubMed: 1830357] http://dx.doi.org/10.1111/j.1365-2958.1991.tb00752.x
	Fernandez-Tornero C, Garcia E, Lopez R, Gimenez-Gallego G, Romero A. Two new crystal forms of the choline-binding domain of the major pneumococcal autolysin: insights into the dynamics of the active homodimer. J. Mol. Biol. 321 2002 163-73 [PubMed: 12139941] http://dx.doi.org/10.1016/S0022-2836(02)00596-X
	Perez-Dorado I, Campillo NE, Monterroso B, Hesek D, Lee M, Paez JA, Garcia P, Martinez-Ripoll M, Garcia JL, Mobashery S, Menendez M, Hermoso JA. Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1. J. Biol. Chem. 282 2007 24990-9 [PubMed: 17581815] http://dx.doi.org/10.1074/jbc.M704317200
	Sanchez-Beato AR, Ronda C, Garcia JL. Tracking the evolution of the bacterial choline-binding domain: molecular characterization of the Clostridium acetobutylicum NCIB 8052 cspA gene. J. Bacteriol. 177 1995 1098-103 [PubMed: 7860591] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7860591&action=stream&blobtype=pdf
	Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A. Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors. J. Biol. Chem. 280 2005 19948-57 [PubMed: 15769740] http://dx.doi.org/10.1074/jbc.M501236200

InterPro 23.1