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InterPro: IPR002347 Glucose/ribitol dehydrogenase

Protein matches Help

UniProtKB

Matches:

42676 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002347 Glc/ribitol_DH

Type

Family

Signatures Help

Database	ID	Name	Proteins
PRINTS	PR00081	GDHRDH	42676
Signatures in BioMart

InterPro Relationships Help

Parent

IPR002198 Short-chain dehydrogenase/reductase SDR

Children

IPR005979 Light-dependent protochlorophyllide reductase
IPR006393 Sepiapterin reductase
IPR011283 Acetoacetyl-CoA reductase
IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase
IPR011285 3-oxoacyl-(acyl-carrier-protein) reductase, putative
IPR011286 2-deoxy-D-gluconate 3-dehydrogenase
IPR011294 3-hydroxybutyrate dehydrogenase
IPR011348 17beta-dehydrogenase
IPR012115 Bifunctional ribulose 5-phosphate reductase/CDP-ribitol pyrophosphorylase
IPR014007 Acetoin reductase
IPR014058 Pteridine reductase
IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH)
IPR017619 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase
IPR017711 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

Contains

IPR016040 NAD(P)-binding domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site

GO Term annotation Help

Process

GO:0008152 metabolic process
GO:0055114 oxidation reduction

Function

GO:0016491 oxidoreductase activity

InterPro annotation

Entry Details in BioMart

Abstract

Glucose dehydrogenase catalyses the oxidation of D-glucose without prior phosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme. The enzyme is a tetrameric protein, each of the 4 identical subunits containing 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases and reductases. A match to this extension indicates that the protein is not an alcohol dehydrogenase, but another type of dehydrogenase or reductase.

Structural links Help

PDB - click here

SCOP: c.2.1.2

CATH: 3.40.50.720

Database links Help

Blocks: IPB002347

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002347

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6ZLA1 3-ketoacyl-CoA reductase

O16925 Putative steroid dehydrogenase 4

O18404 3-hydroxyacyl-CoA dehydrogenase type-2

O75828 Carbonyl reductase [NADPH] 3

P08074 Carbonyl reductase [NADPH] 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020904	Short-chain dehydrogenase/reductase, conserved site
IPR016040	NAD(P)-binding domain
IPR002347	Glucose/ribitol dehydrogenase
IPR002198	Short-chain dehydrogenase/reductase SDR
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Jany KD, Ulmer W, Froschle M, Pfleiderer G. Complete amino acid sequence of glucose dehydrogenase from Bacillus megaterium. FEBS Lett. 165 1984 6-10 [PubMed: 6420184] http://dx.doi.org/10.1016/0014-5793(84)80003-4
	Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z. Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. Bioorg. Med. Chem. 16 2008 8922-31 [PubMed: 18789704] http://dx.doi.org/10.1016/j.bmc.2008.08.065
	Hale C, Veniant M, Wang Z, Chen M, McCormick J, Cupples R, Hickman D, Min X, Sudom A, Xu H, Matsumoto G, Fotsch C, St Jean DJ Jr, Wang M. Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor. 71 2008 36-44 [PubMed: 18069989] http://dx.doi.org/10.1111/j.1747-0285.2007.00603.x
	Yamada M, Saier MH Jr. Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon. J. Biol. Chem. 262 1987 5455-63 [PubMed: 3553176] http://intl.jbc.org/cgi/reprint/262/12/5455.pdf
	Cavazzuti A, Paglietti G, Hunter WN, Gamarro F, Piras S, Loriga M, Allecca S, Corona P, McLuskey K, Tulloch L, Gibellini F, Ferrari S, Costi MP. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc. Natl. Acad. Sci. U.S.A. 105 2008 1448-53 [PubMed: 18245389] http://dx.doi.org/10.1073/pnas.0704384105
	Julian LD, Wang Z, Bostick T, Caille S, Choi R, DeGraffenreid M, Di Y, He X, Hungate RW, Jaen JC, Liu J, Monshouwer M, McMinn D, Rew Y, Sudom A, Sun D, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model. J. Med. Chem. 51 2008 3953-60 [PubMed: 18553955] http://dx.doi.org/10.1021/jm800310g
	Sun D, Wang Z, Di Y, Jaen JC, Labelle M, Ma J, Miao S, Sudom A, Tang L, Tomooka CS, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg. Med. Chem. Lett. 18 2008 3513-6 [PubMed: 18511278] http://dx.doi.org/10.1016/j.bmcl.2008.05.025

InterPro 23.1