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InterPro: IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding

Protein matches Help

UniProtKB

Matches:

2157 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002192 PPDK_PEP_bd

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01326	PPDK_N	2157
Signatures in BioMart

InterPro Relationships Help

Found in

IPR006319 Phosphoenolpyruvate synthase
IPR010121 Pyruvate, phosphate dikinase

Contains

IPR013815 ATP-grasp fold, subdomain 1

GO Term annotation Help

Process

GO:0016310 phosphorylation

Function

GO:0005524 ATP binding
GO:0016301 kinase activity

InterPro annotation

Entry Details in BioMart

Abstract

This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP) [1]. Residues at the N terminus correspond to the transit peptide which is indispensable for the transport of the precursor protein into chloroplasts in plants [2]. This domain is present at the N terminus of some PEP-utilizing enzymes.

Structural links Help

PDB - click here

SCOP: d.142.1.5

CATH: 1.10.189.10 , 1.20.80.30 , 3.30.1490.20 , 3.30.470.20

Database links Help

Enzyme: EC:2.7.9

PANDIT: PF01326

Blocks: IPB002192

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002192

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O23404 Pyruvate, phosphate dikinase 1, chloroplastic

O27190 Probable phosphoenolpyruvate synthase

P22983 Pyruvate, phosphate dikinase

Q2QTC2 Phosphoglucan, water dikinase, chloroplastic

Q55905 Phosphoenolpyruvate synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002044	Glycoside hydrolase, carbohydrate-binding
IPR013784	Carbohydrate-binding-like fold
IPR013815	ATP-grasp fold, subdomain 1
IPR013816	ATP-grasp fold, subdomain 2
IPR000121	PEP-utilising enzyme
IPR002192	Pyruvate phosphate dikinase, PEP/pyruvate-binding
IPR013783	Immunoglobulin-like fold
IPR010121	Pyruvate, phosphate dikinase
IPR008279	PEP-utilising enzyme, mobile domain
IPR018274	PEP-utilising enzyme, mobile region, conserved site
IPR006319	Phosphoenolpyruvate synthase
IPR015813	Pyruvate/Phosphoenolpyruvate kinase, catalytic core
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Herzberg O, Chen CC, Kapadia G, McGuire M, Carroll LJ, Noh SJ, Dunaway-Mariano D. Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites. Proc. Natl. Acad. Sci. U.S.A. 93 2652-7 1996 [PubMed: 8610096] http://dx.doi.org/10.1073/pnas.93.7.2652
2.	Matsuoka M, Ozeki Y, Yamamoto N, Hirano H, Kano-Murakami Y, Tanaka Y. Primary structure of maize pyruvate, orthophosphate dikinase as deduced from cDNA sequence. J. Biol. Chem. 263 11080-3 1988 [PubMed: 2841317] http://intl.jbc.org/cgi/reprint/263/23/11080.pdf

Additional Reading Open in usermanual
	Cosenza LW, Bringaud F, Baltz T, Vellieux FM. The 3.0 A resolution crystal structure of glycosomal pyruvate phosphate dikinase from Trypanosoma brucei. J. Mol. Biol. 318 2002 1417-32 [PubMed: 12083528] http://dx.doi.org/10.1016/S0022-2836(02)00113-4
	Herzberg O, Chen CC, Liu S, Tempczyk A, Howard A, Wei M, Ye D, Dunaway-Mariano D. Pyruvate site of pyruvate phosphate dikinase: crystal structure of the enzyme-phosphonopyruvate complex, and mutant analysis. Biochemistry 41 2002 780-7 [PubMed: 11790099] http://dx.doi.org/10.1021/bi011799+
	Lim K, Read RJ, Chen CC, Tempczyk A, Wei M, Ye D, Wu C, Dunaway-Mariano D, Herzberg O. Swiveling domain mechanism in pyruvate phosphate dikinase. Biochemistry 46 2007 14845-53 [PubMed: 18052212] http://dx.doi.org/10.1021/bi701848w
	Nakanishi T, Nakatsu T, Matsuoka M, Sakata K, Kato H. Crystal structures of pyruvate phosphate dikinase from maize revealed an alternative conformation in the swiveling-domain motion. Biochemistry 44 2005 1136-44 [PubMed: 15667207] http://dx.doi.org/10.1021/bi0484522
	Nakanishi T, Ohki Y, Oda J, Matsuoka M, Sakata K, Kato H. Purification, crystallization and preliminary X-ray diffraction studies on pyruvate phosphate dikinase from maize. Acta Crystallogr. D Biol. Crystallogr. 60 2004 193-4 [PubMed: 14684927]

InterPro 23.1