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InterPro: IPR002168 Lipase, GDXG, active site

Protein matches Help

UniProtKB

Matches:

1601 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR002168 Lipase_GDXG_AS

Type

Active_site

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS01173	LIPASE_GDXG_HIS	1063
PROSITE pattern	PS01174	LIPASE_GDXG_SER	856
Signatures in BioMart

InterPro Relationships Help

Found in

IPR013094 Alpha/beta hydrolase fold-3
IPR017157 Arylacetamide deacetylase

GO Term annotation Help

Process

GO:0008152 metabolic process

Function

GO:0016787 hydrolase activity

InterPro annotation

Entry Details in BioMart

Abstract

These enzymes contain a Ser-centred consensus sequence and a conserved His-Gly dipeptide found in most lipase amino-terminal domains. These sequences are involved in the lipase active site conformation since substitution of the conserved Ser or His residues by Ala and Gln, respectively, results in the loss of both lipase and esterase activities [1].

Structural links Help

PDB - click here

CATH: 3.40.50.1820

Database links Help

PDBe-motif: PS01173 , PS01174

Enzyme: EC:3.1.1

PROSITE doc: PDOC00903

Blocks: IPB002168

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002168

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P22760 Arylacetamide deacetylase

P54310 Hormone-sensitive lipase

Q6L545 Gibberellin receptor GID1

Q8ZRA1 Acetyl esterase

Q9MAA7 Probable gibberellin receptor GID1L1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013094	Alpha/beta hydrolase fold-3
IPR017157	Arylacetamide deacetylase
IPR002168	Lipase, GDXG, active site
IPR010468	Hormone-sensitive lipase, N-terminal
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Feller G, Thiry M, Gerday C. Nucleotide sequence of the lipase gene lip2 from the antarctic psychrotroph Moraxella TA144 and site-specific mutagenesis of the conserved serine and histidine residues. DNA Cell Biol. 10 381-8 1991 [PubMed: 1907455]

Additional Reading Open in usermanual
	Byun JS, Rhee JK, Kim ND, Yoon J, Kim DU, Koh E, Oh JW, Cho HS. Crystal structure of hyperthermophilic esterase EstE1 and the relationship between its dimerization and thermostability properties. BMC Struct. Biol. 7 2007 47 [PubMed: 17625021] http://dx.doi.org/10.1186/1472-6807-7-47

InterPro 23.1