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InterPro: IPR002087 Anti-proliferative protein

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UniProtKB

Matches:

181 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR002087 Anti_prolifrtn

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07742	BTG	181
PRINTS	PR00310	ANTIPRLFBTG1	160
PROSITE pattern	PS00960	BTG_1	86
PROSITE pattern	PS01203	BTG_2	136
SMART	SM00099	btg1	86
Signatures in BioMart

InterPro Relationships Help

Found in

IPR015676 Transducer of ErbB-2
IPR015677 Transducer of ErbB-2, 1
IPR015678 Transducer of ErbB-2, 2

InterPro annotation

Entry Details in BioMart

Abstract

Anti-proliferative proteins have been shown to include mammalian and avian protein BTG1 (which appears to be involved in negative regulation of cell proliferation) and rat/mouse NGF-inducible protein PC3/TIS21 (BTG2) [1, 2, 3]. These proteins have from 158 to 363 amino acid residues, that are highly similar and include 3 conserved cysteine residues. BTG2 seems to have a signal sequence; while the other proteins may lack such a domain. The sequence of the N-terminal half of these proteins is well conserved.

Structural links Help

PDB - click here

SCOP: d.370.1.1

Database links Help

PDBe-motif: PS00960 , PS01203

PROSITE doc: PDOC00742

PANDIT: PF07742

Blocks: IPB002087

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR002087

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A4UTQ2 Protein BTG3

P50616 Protein Tob1

Q04211 Protein BTG2

Q54NU5 BTG family protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002087	Anti-proliferative protein
IPR015676	Transducer of ErbB-2
IPR015677	Transducer of ErbB-2, 1
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Rouault JP, Rimokh R, Tessa C, Paranhos G, Ffrench M, Duret L, Garoccio M, Germain D, Samarut J, Magaud JP. BTG1, a member of a new family of antiproliferative genes. EMBO J. 11 1663-70 1992 [PubMed: 1373383] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=1373383&action=stream&blobtype=pdf
2.	Rouault JP, Samarut C, Duret L, Tessa C, Samarut J, Magaud JP. Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions. Gene 129 303-6 1993 [PubMed: 8325512] http://dx.doi.org/10.1016/0378-1119(93)90284-A
3.	Bradbury A, Possenti R, Shooter EM, Tirone F. Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Proc. Natl. Acad. Sci. U.S.A. 88 3353-7 1991 [PubMed: 1849653] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=1849653&action=stream&blobtype=pdf

Additional Reading Open in usermanual
	Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, Onda M, Yoshida Y, Nishiyama A, Yamamoto T. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. Oncogene 12 1996 705-13 [PubMed: 8632892]

InterPro 23.1