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InterPro: IPR001993 Mitochondrial substrate carrier

Protein matchesHelp
UniProtKB
Matches:
6688 proteins
AccessionHelp IPR001993 Mitochondria_substrate_carrier
TypeHelp Family
SignaturesHelp
InterPro RelationshipsHelp
Children IPR002067 Mitochondrial carrier protein
Contains IPR018108 Mitochondrial substrate/solute carrier
GO Term annotationHelp
Process GO:0006810 transport
GO:0055085 transmembrane transport
Function GO:0005488 binding
Component GO:0016020 membrane
InterPro annotation
BioMart Logo Entry Details in BioMart
AbstractHelp

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome [1, 2, 3, 4, 5, 6]. Such proteins include: ADP, ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.

Structural linksHelp
SCOP: f.42.1.1
Database linksHelp
PROSITE doc: PDOC00189
PANDIT: PF00153
Blocks: IPB001993

Taxonomic coverageHelp

Overlapping InterPro entriesHelp
IPR001993 Numbers of overlapping proteins Average numbers of overlapping amino acids

Example proteinsHelp
A2A3V2 Solute carrier family 25 member 43

A6ZV78 Mitochondrial thiamine pyrophosphate carrier 1

O43772 Mitochondrial carnitine/acylcarnitine carrier protein

P34519 Putative tricarboxylate transport protein, mitochondrial

Q26365 ADP,ATP carrier protein

More proteins


Example Proteins Key


InterPro entry accession number/name and structure databases Colour code
IPR002067 Mitochondrial carrier protein
IPR002113 Adenine nucleotide translocator 1
IPR018108 Mitochondrial substrate/solute carrier
IPR001993 Mitochondrial substrate carrier
SWISS-MODEL
ModBase

PublicationsHelp
1. Klingenberg M.
Mechanism and evolution of the uncoupling protein of brown adipose tissue.
Trends Biochem. Sci. 15 108-12 1990 [PubMed: 2158156]
http://dx.doi.org/10.1016/0968-0004(90)90194-G
2. Walker JE.
The mitochondrial transporter family.
Curr. Opin. Struct. Biol. 2 519-26 1992
3. Kuan J, Saier MH Jr.
Expansion of the mitochondrial carrier family.
Res. Microbiol. 144 671-2 1993 [PubMed: 8140286]
http://dx.doi.org/10.1016/0923-2508(93)90073-B
4. Nelson DR, Lawson JE, Klingenberg M, Douglas MG.
Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential.
J. Mol. Biol. 230 1159-70 1993 [PubMed: 8487299]
http://dx.doi.org/10.1006/jmbi.1993.1233
5. Palmieri F.
Mitochondrial carrier proteins.
FEBS Lett. 346 48-54 1994 [PubMed: 8206158]
http://dx.doi.org/10.1016/0014-5793(94)00329-7
6. Jank B, Habermann B, Schweyen RJ, Link TA.
PMP47, a peroxisomal homologue of mitochondrial solute carrier proteins.
Trends Biochem. Sci. 18 427-8 1993 [PubMed: 8291088]
http://dx.doi.org/10.1016/0968-0004(93)90141-9

Additional ReadingHelp
Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G.
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.
Nature 426 2003 39-44 [PubMed: 14603310]
http://dx.doi.org/10.1038/nature02056
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InterPro 23.1