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InterPro: IPR001962 Asparagine synthase

Protein matches Help

UniProtKB

Matches:

2424 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001962 Asn_synthase

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00733	Asn_synthase	2424
Signatures in BioMart

InterPro Relationships Help

Parent

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

Found in

IPR006426 Asparagine synthase, glutamine-hydrolyzing
IPR017535 Asparagine synthase family amidotransferase
IPR017539 Exosortase 1 system-associated amidotransferase 1

GO Term annotation Help

Process

GO:0006529 asparagine biosynthetic process

Function

GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity

InterPro annotation

Entry Details in BioMart

Abstract

This domain is always found associated with (IPR000583). Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B (EC:6.3.5.4) catalyzes the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine. The three-dimensional architecture of the N-terminal domain of asparagine synthetase B is similar to that observed for glutamine phosphoribosylpyrophosphate amidotransferase while the molecular motif of the C-domain is reminiscent to that observed for GMP synthetase [1].

Structural links Help

PDB - click here

SCOP: c.26.2.1

CATH: 3.40.50.620

Database links Help

PANDIT: PF00733

Blocks: IPB001962

Pfam Clan: CL0039.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001962

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P08243 Asparagine synthetase [glutamine-hydrolyzing]

P49078 Asparagine synthetase [glutamine-hydrolyzing]

P49089 Asparagine synthetase [glutamine-hydrolyzing] 1

Q5LJP9 Asparagine synthetase domain-containing protein CG17486

Q61024 Asparagine synthetase [glutamine-hydrolyzing]

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000583	Glutamine amidotransferase, class-II
IPR006426	Asparagine synthase, glutamine-hydrolyzing
IPR001962	Asparagine synthase
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR017932	Glutamine amidotransferase, type II
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry 38 16146-57 1999 [PubMed: 10587437] http://dx.doi.org/10.1021/bi9915768

Additional Reading Open in usermanual
	Miller MT, Gerratana B, Stapon A, Townsend CA, Rosenzweig AC. Crystal structure of carbapenam synthetase (CarA). J. Biol. Chem. 278 2003 40996-1002 [PubMed: 12890666] http://dx.doi.org/10.1074/jbc.M307901200
	Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proc. Natl. Acad. Sci. U.S.A. 99 2002 14752-7 [PubMed: 12409610] http://dx.doi.org/10.1073/pnas.232361199
	Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nat. Struct. Biol. 8 2001 684-9 [PubMed: 11473258] http://dx.doi.org/10.1038/90394

InterPro 23.1