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InterPro: IPR001950 Translation initiation factor SUI1

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UniProtKB

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1170 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR001950 TIF_SUI1

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF01253	SUI1	1152
PROSITE profile	PS50296	SUI1	1157
SuperFamily	SSF55159	TIF_SUI1	1139
Signatures in BioMart

InterPro Relationships Help

Found in

IPR005872 Archaeal/bacterial translation initiation factor SUI1
IPR005873 Density-regulated protein DRP1
IPR005874 Eukaryotic translation initiation factor SUI1
IPR017228 Translation initiation factor 1, prokaryotic

GO Term annotation Help

Process

GO:0006413 translational initiation

Function

GO:0003743 translation initiation factor activity

InterPro annotation

Entry Details in BioMart

Abstract

In Saccharomyces cerevisiae (Baker's yeast), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [1]. SUI1 is a protein of 108 residues. Close homologs of SUI1 have been found [2] in mammals, insects and plants. SUI1 is also evolutionary related to hypothetical proteins from Escherichia coli (yciH), Haemophilus influenzae (HI1225) and Methanococcus vannielii.

Structural links Help

PDB - click here

SCOP: d.64.1.1

CATH: 3.30.780.10

Database links Help

PROSITE doc: PDOC00862

PANDIT: PF01253

Blocks: IPB001950

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001950

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P32911 Eukaryotic translation initiation factor eIF-1

P41567 Eukaryotic translation initiation factor 1

P48024 Eukaryotic translation initiation factor 1

Q9NAH4 Density-regulated protein homolog

Q9VYI3 Probable 39S ribosomal protein L49, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007740	Ribosomal protein L49/IMG2
IPR001950	Translation initiation factor SUI1
IPR005873	Density-regulated protein DRP1
IPR005874	Eukaryotic translation initiation factor SUI1
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Yoon HJ, Donahue TF. The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. Mol. Cell. Biol. 12 248-60 1992 [PubMed: 1729602] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=1729602
2.	Fields C, Adams MD. Expressed sequence tags identify a human isolog of the suil translation initiation factor. Biochem. Biophys. Res. Commun. 198 288-91 1994 [PubMed: 7904817] http://dx.doi.org/10.1006/bbrc.1994.1040

Additional Reading Open in usermanual
	Fletcher CM, Pestova TV, Hellen CU, Wagner G. Structure and interactions of the translation initiation factor eIF1. EMBO J. 18 1999 2631-7 [PubMed: 10228174] http://dx.doi.org/10.1093/emboj/18.9.2631
	Cort JR, Koonin EV, Bash PA, Kennedy MA. A phylogenetic approach to target selection for structural genomics: solution structure of YciH. Nucleic Acids Res. 27 1999 4018-27 [PubMed: 10497266] http://dx.doi.org/10.1093/nar/27.20.4018

InterPro 23.1