InterPro: IPR001710 Adrenomedullin

Adrenomedullin is a hypotensive peptide, first identified in human pheochromocytoma arising from adrenal medulla [1, 2]. The protein is ~185 amino acids in length, and includes a 21-residue putative N-terminal signal sequence [2]. The active peptide, which is expressed in adrenal glands, lung, kidney, heart, spleen, duodenum and submandibular glands, is thought to function as a hormone in circulation control.

The adrenomedullin precursor is believed to contain 2 cleavage sites, one of which produces the active adrenomedullin hormone, and the other, a 20-residue peptide (proadrenomedullin N-terminal 20 peptide, or proam-n20) of unknown function [3].