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InterPro: IPR001701 Glycoside hydrolase, family 9

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UniProtKB

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962 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR001701 Glyco_hydro_9

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00759	Glyco_hydro_9	962
PANTHER	PTHR22298:SF3	Glyco_hydro_9	849
Signatures in BioMart

InterPro Relationships Help

Contains

IPR012341 Six-hairpin glycosidase
IPR018221 Glycoside hydrolase, family 9, active site

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glycoside hydrolase family 9 GH9 comprises enzymes with several known activities; endoglucanase (EC:3.2.1.4); cellobiohydrolase (EC:3.2.1.91). These enzymes were formerly known as cellulase family E.

Structural links Help

PDB - click here

SCOP: a.102.1.2 , b.2.2.2

CATH: 1.50.10.10 , 2.60.40.710

Database links Help

PDBe-motif: PS00592 , PS00698

Enzyme: EC:3.2.1.4

CAZy: GH9

PROSITE doc: PDOC00511

PANDIT: PF00759

Blocks: IPB001701

Pfam Clan: CL0059.11

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR001701

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2XYW8 Endoglucanase 13

O04478 Endoglucanase 7

P05522 Endoglucanase 1

P14090 Endoglucanase C

P22699 Endoglucanase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003305	Carbohydrate-binding, CenC-like
IPR007110	Immunoglobulin-like
IPR003599	Immunoglobulin subtype
IPR001701	Glycoside hydrolase, family 9
IPR013783	Immunoglobulin-like fold
IPR004197	Glycoside hydrolase, family 9, N-terminal, Ig-like
IPR014756	Immunoglobulin E-set
IPR013098	Immunoglobulin I-set
IPR019028	Carbohydrate binding domain CBM49
IPR012341	Six-hairpin glycosidase
IPR008928	Six-hairpin glycosidase-like
IPR008979	Galactose-binding domain-like
IPR018221	Glycoside hydrolase, family 9, active site
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999

Additional Reading Open in usermanual
	Schubot FD, Kataeva IA, Chang J, Shah AK, Ljungdahl LG, Rose JP, Wang BC. Structural basis for the exocellulase activity of the cellobiohydrolase CbhA from Clostridium thermocellum. Biochemistry 43 2004 1163-70 [PubMed: 14756552] http://dx.doi.org/10.1021/bi030202i
	Parsiegla G, Belaich A, Belaich JP, Haser R. Crystal structure of the cellulase Cel9M enlightens structure/function relationships of the variable catalytic modules in glycoside hydrolases. Biochemistry 41 2002 11134-42 [PubMed: 12220178] http://dx.doi.org/10.1021/bi025816m
	Sakon J, Irwin D, Wilson DB, Karplus PA. Structure and mechanism of endo/exocellulase E4 from Thermomonospora fusca. Nat. Struct. Biol. 4 1997 810-8 [PubMed: 9334746] http://dx.doi.org/10.1038/nsb1097-810
	Mandelman D, Belaich A, Belaich JP, Aghajari N, Driguez H, Haser R. X-Ray crystal structure of the multidomain endoglucanase Cel9G from Clostridium cellulolyticum complexed with natural and synthetic cello-oligosaccharides. J. Bacteriol. 185 2003 4127-35 [PubMed: 12837787] http://dx.doi.org/10.1128/JB.185.14.4127-4135.2003
	Khademi S, Guarino LA, Watanabe H, Tokuda G, Meyer EF. Structure of an endoglucanase from termite, Nasutitermes takasagoensis. Acta Crystallogr. D Biol. Crystallogr. 58 2002 653-9 [PubMed: 11914490] http://dx.doi.org/10.1107/S0907444902002366

InterPro 23.1